The American journal of clinical nutrition · 2026
25-Hydroxyvitamin D3 bioenriched chicken and eggs maintained vitamin D status over the winter in healthy-adult males and females: a randomized controlled trial.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Xie Yuke, Kalia Sahil, Ou Keith J, Sun Tao, Bender Erica, Lin Kimberly, Bottje Walter, Lei Xingen, O'Brien Kimberly O
Аннотация
BACKGROUND: Vitamin D insufficiency remains a concern in the United States because of limited natural food sources and insufficient ultraviolet B radiation exposure. Biofortification of poultry and eggs with vitamin D or 25-hydroxyvitamin D (25(OH)D) is a potential strategy to improve vitamin D status.
OBJECTIVES: This study aims to assess whether biofortification of chicken and eggs with 25(OH)D3 increases total serum 25(OH)D concentrations compared with vitamin D3 supplementation.
METHODS: Participants (n = 57) were randomly assigned into 3 groups for an 8-wk winter intervention. Participants received chicken during weeks 1-8 and eggs during weeks 5-8. The 25D3 group (n = 19) received 25(OH)D3 biofortified chicken and eggs with daily Placebo pills. The D3 group (n = 19) received control chicken and eggs with a daily vitamin D3 supplement (1000 IU/d). The Placebo group (n = 19) received control chicken and eggs with daily Placebo pills. Biweekly blood samples were collected to measure vitamin D metabolites using liquid chromatography-tandem mass spectrometry. Changes in vitamin D metabolites over time were assessed using mixed-effects models.
RESULTS: Vitamin D3 supplementation significantly increased total serum 25(OH)D by 4.3 ng/mL over 8 wk [95% confidence interval (CI): 1.0, 7.5; P < 0.05], whereas 25(OH)D3 biofortification maintained serum 25(OH)D at baseline concentrations. Individuals in the Placebo group experienced a significant decline in serum 25(OH)D concentrations by 4.4 ng/mL (95% CI: -7.7, -1.7; P < 0.05).
CONCLUSIONS: 25(OH)D3 biofortification of chicken and eggs prevented the seasonal decline in serum 25(OH)D observed in healthy young adults not taking vitamin D3 supplements but was not as effective as a daily 1000-IU vitamin D3 supplement. This study was registered at clinicaltrials.gov as NCT05248737 (https://clinicaltrials.gov/study/NCT05248737).
OBJECTIVES: This study aims to assess whether biofortification of chicken and eggs with 25(OH)D3 increases total serum 25(OH)D concentrations compared with vitamin D3 supplementation.
METHODS: Participants (n = 57) were randomly assigned into 3 groups for an 8-wk winter intervention. Participants received chicken during weeks 1-8 and eggs during weeks 5-8. The 25D3 group (n = 19) received 25(OH)D3 biofortified chicken and eggs with daily Placebo pills. The D3 group (n = 19) received control chicken and eggs with a daily vitamin D3 supplement (1000 IU/d). The Placebo group (n = 19) received control chicken and eggs with daily Placebo pills. Biweekly blood samples were collected to measure vitamin D metabolites using liquid chromatography-tandem mass spectrometry. Changes in vitamin D metabolites over time were assessed using mixed-effects models.
RESULTS: Vitamin D3 supplementation significantly increased total serum 25(OH)D by 4.3 ng/mL over 8 wk [95% confidence interval (CI): 1.0, 7.5; P < 0.05], whereas 25(OH)D3 biofortification maintained serum 25(OH)D at baseline concentrations. Individuals in the Placebo group experienced a significant decline in serum 25(OH)D concentrations by 4.4 ng/mL (95% CI: -7.7, -1.7; P < 0.05).
CONCLUSIONS: 25(OH)D3 biofortification of chicken and eggs prevented the seasonal decline in serum 25(OH)D observed in healthy young adults not taking vitamin D3 supplements but was not as effective as a daily 1000-IU vitamin D3 supplement. This study was registered at clinicaltrials.gov as NCT05248737 (https://clinicaltrials.gov/study/NCT05248737).