Modern rheumatology · 2026
Prospective follow-up of patients with probable Behçet's disease: first results of an inception cohort.
СтатьяНазвание и аннотация: Перевод в очереди
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Karakök Özge, Kutluğ-Ağaçkıran Seda, Ergelen Rabia, Ergun Tülin, Direskeneli Haner, Alibaz-Oner Fatma
Аннотация
OBJECTIVE: We aimed to follow patients classified as probable Behçet's disease (BD) prospectively, conducting an inception cohort with patients diagnosed only within the last 6 months.
METHODS: We included 55 patients with probable BD. Fulfilment of classification criteria, new major organ involvement, and immunosuppressive (IS) usage were assessed during follow-up.
RESULTS: Initially, no patient fulfilled the International Study Group criteria. The median follow-up duration was 48 (21-77.5) months. Initially, 45 (81.8%) patients had major organ involvement. In 51 (92.7%) patients, bilateral common femoral vein wall thickness exceeded the 0.5 mm cut-off (Bilateral median common femoral vein wall thickness: 0.7 mm (0.70-0.80)). During follow-up, new major organ involvement was observed in 16 (29.1%) patients who needed step-up treatment with ISs. Six patients (10.9%) also developed new symptoms and subsequently fulfilled one or more diagnostic criteria. Two (3.6%) patients with pulmonary artery aneurysm had deceased due to massive haemoptysis.
CONCLUSIONS: According to the 48-month follow-up results of the probable BD inception cohort, the majority of BD patients who had limited clinical findings started with major organ involvement. Only six (10.9%) patients developed new manifestations during follow-up, and these patients subsequently met the International Study Group and/or International Criteria for Behçet's Disease criteria. Additionally, 16 patients (29.1%) experienced new or relapsed major organ involvement.
METHODS: We included 55 patients with probable BD. Fulfilment of classification criteria, new major organ involvement, and immunosuppressive (IS) usage were assessed during follow-up.
RESULTS: Initially, no patient fulfilled the International Study Group criteria. The median follow-up duration was 48 (21-77.5) months. Initially, 45 (81.8%) patients had major organ involvement. In 51 (92.7%) patients, bilateral common femoral vein wall thickness exceeded the 0.5 mm cut-off (Bilateral median common femoral vein wall thickness: 0.7 mm (0.70-0.80)). During follow-up, new major organ involvement was observed in 16 (29.1%) patients who needed step-up treatment with ISs. Six patients (10.9%) also developed new symptoms and subsequently fulfilled one or more diagnostic criteria. Two (3.6%) patients with pulmonary artery aneurysm had deceased due to massive haemoptysis.
CONCLUSIONS: According to the 48-month follow-up results of the probable BD inception cohort, the majority of BD patients who had limited clinical findings started with major organ involvement. Only six (10.9%) patients developed new manifestations during follow-up, and these patients subsequently met the International Study Group and/or International Criteria for Behçet's Disease criteria. Additionally, 16 patients (29.1%) experienced new or relapsed major organ involvement.