Journal of ethnopharmacology · 2025
Anti-inflammatory activity, spermidine alkaloids, and other chemical constituents of the decoction from Tarenaya aculeata stems.
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Duarte Bianca Ferreira, Procopio Elisangela Dos Santos, de Matos Balsalobre Natália, da Rosa Guterres Zaira, Leite Kassuya Candida Aparecida, da Silva Pinto Luciano, Ferreira Moraes Carlos André, Soares Neto Raimundo Luciano, Nogueira Cláudio Rodrigo, Lima Cardoso Claudia Andrea
Аннотация
ETHNOPHARMACOLOGICAL RELEVANCE: Tarenaya aculeata is traditionally used in Brazil to treat inflammation and pain-related conditions.
AIM OF THE STUDY: This study aimed to investigate the chemical composition, anti-inflammatory potential, and genotoxicity of a freeze-dried stem decoction of T. aculeata (SE) and a fraction free of the bulk of water-soluble compounds (SF).
MATERIAL AND METHODS: The SE and SF samples were chemically characterized using UHPLC-ESI-QTOF-MS/MS. The anti-inflammatory activity was evaluated at three doses (SE: 30, 100, and 300 mg/kg; SF: 10, 30, and 100 mg/kg) using carrageenan-induced paw edema and pleurisy models, while genotoxicity was assessed using the SMART test.
RESULTS: A total of 35 compounds were annotated: one cyanogenic glycoside; three glucosinolates; one benzoic acid derivative; one indole alkaloid; five spermidine alkaloids; six flavonoids; four sesquilignans; and fourteen miscellaneous compounds. Among them, seven new compounds: 4-cyano-4-hydroxybutanoic acid hexoside; tarenayanines A1, B1, C1, and D1; quercetin-sinapoyl-rhamnosyl-hexosyl-hexosyl-rhamnoside; and tarenayolone. SE and SF were not genotoxic and significantly reduced inflammatory parameters and pain sensitivity thresholds. The analgesic effect of SE was observed at 300 mg/kg, while those of SF at 100 mg/kg. SE significantly reduced edema at 100 and 300 mg/kg at 3 and/or 4 h post-induction, preventing mechanical hyperalgesia. SF inhibited edema only at 100 mg/kg, 3 and 4 h after administration. Both samples decreased leukocyte migration to pleural exudate significantly.
CONCLUSION: SE and SF showed in vivo anti-inflammatory action and were found to be rich in compounds associated with this therapeutic effect, supporting the use of T. aculeata for inflammation management.
AIM OF THE STUDY: This study aimed to investigate the chemical composition, anti-inflammatory potential, and genotoxicity of a freeze-dried stem decoction of T. aculeata (SE) and a fraction free of the bulk of water-soluble compounds (SF).
MATERIAL AND METHODS: The SE and SF samples were chemically characterized using UHPLC-ESI-QTOF-MS/MS. The anti-inflammatory activity was evaluated at three doses (SE: 30, 100, and 300 mg/kg; SF: 10, 30, and 100 mg/kg) using carrageenan-induced paw edema and pleurisy models, while genotoxicity was assessed using the SMART test.
RESULTS: A total of 35 compounds were annotated: one cyanogenic glycoside; three glucosinolates; one benzoic acid derivative; one indole alkaloid; five spermidine alkaloids; six flavonoids; four sesquilignans; and fourteen miscellaneous compounds. Among them, seven new compounds: 4-cyano-4-hydroxybutanoic acid hexoside; tarenayanines A1, B1, C1, and D1; quercetin-sinapoyl-rhamnosyl-hexosyl-hexosyl-rhamnoside; and tarenayolone. SE and SF were not genotoxic and significantly reduced inflammatory parameters and pain sensitivity thresholds. The analgesic effect of SE was observed at 300 mg/kg, while those of SF at 100 mg/kg. SE significantly reduced edema at 100 and 300 mg/kg at 3 and/or 4 h post-induction, preventing mechanical hyperalgesia. SF inhibited edema only at 100 mg/kg, 3 and 4 h after administration. Both samples decreased leukocyte migration to pleural exudate significantly.
CONCLUSION: SE and SF showed in vivo anti-inflammatory action and were found to be rich in compounds associated with this therapeutic effect, supporting the use of T. aculeata for inflammation management.