Cancer medicine · 2026
A Comprehensive Meta-Analysis and Review of Intraoperative Radiotherapy in Colorectal Cancer: Examining Radiation Dosage, Long-Term Prognosis, and Treatment-Related Complications.
СтатьяМетаанализСистематический обзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Guo Chuhan, Liu Shuyang, Li Liangliang, Zhao Jiayi, Zhou Hongji, Liu Hongqiang, Liu Tong, Ji Fujian
Аннотация
BACKGROUND: The effect of device type and radiation dose in intraoperative radiotherapy (IORT) for colorectal cancer is not well established. To explore this, we reviewed studies reporting postoperative complications, disease-free survival, local control, and long-term survival in patients treated with non-implantable IORT techniques-IOERT, KV-IORT, and HDR-IORT. Most of the available evidence relates to IOERT or HDR-IORT, which is usually delivered at 15 Gy (range 10-20 Gy). The median dose for KV-IORT is typically 12.5 Gy.
METHODS: We conducted a systematic search of literature through November 2023 to identify studies that compared non-implantable IORT with surgery alone or other treatment approaches (PROSPERO registration: CRD42024508349). Twenty-five studies involving 2664 patients met the inclusion criteria.
RESULTS: Patients treated with non-implantable IORT tended to achieve better 5-year overall survival than those managed without it, with IOERT contributing most clearly to this difference. A similar pattern emerged for long-term local control, where IORT showed an advantage [OR 2.08, 95% CI 1.19-3.64]; studies of IOERT reported an even stronger effect [OR 2.23, 95% CI 1.07-4.65]. Importantly, the use of IORT did not correspond with higher rates of key postoperative complications, including anastomotic leakage, pelvic collections, wound problems, or bowel obstruction.
CONCLUSIONS: Our results suggest that IORT may improve survival and local control for patients with advanced or recurrent colorectal cancer, despite the heterogeneity among studies. Device-related and dose-related factors may also play a role and merit closer study, thus warranting closer examination in future work.
METHODS: We conducted a systematic search of literature through November 2023 to identify studies that compared non-implantable IORT with surgery alone or other treatment approaches (PROSPERO registration: CRD42024508349). Twenty-five studies involving 2664 patients met the inclusion criteria.
RESULTS: Patients treated with non-implantable IORT tended to achieve better 5-year overall survival than those managed without it, with IOERT contributing most clearly to this difference. A similar pattern emerged for long-term local control, where IORT showed an advantage [OR 2.08, 95% CI 1.19-3.64]; studies of IOERT reported an even stronger effect [OR 2.23, 95% CI 1.07-4.65]. Importantly, the use of IORT did not correspond with higher rates of key postoperative complications, including anastomotic leakage, pelvic collections, wound problems, or bowel obstruction.
CONCLUSIONS: Our results suggest that IORT may improve survival and local control for patients with advanced or recurrent colorectal cancer, despite the heterogeneity among studies. Device-related and dose-related factors may also play a role and merit closer study, thus warranting closer examination in future work.