International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
Septic shock caused by Chromobacterium haemolyticum following initial misidentification as Chromobacterium violaceum in China.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Ye Huiying, Wu Yanhong, Xu Xiaohong, Chen Xuwei, Zhou Tingjie, Zhu Fengjiao, Hu Chuancai, Ning Yongzhong, Bao Danni
Аннотация
OBJECTIVES: We report a case of bloodstream infection caused by Chromobacterium haemolyticum in an 80-year-old man following traumatic exposure to contaminated rice field water. The patient presented with rapidly progressive lower extremity soft tissue infection and septic shock.
DESIGN OR METHODS: Initial identification was performed using MALDI-TOF MS. Due to atypical phenotypic characteristics, including absence of violacein pigmentation and presence of β-hemolysis, whole-genome sequencing (WGS) was conducted for definitive species confirmation.
RESULT: Preliminary MALDI-TOF MS identification indicates that it is Chromobacterium violaceum; Definitive identification by whole-genome sequencing (WGS) confirmed C. haemolyticum. Antimicrobial susceptibility testing (AST) revealed high-level resistance to β-lactam antibiotics, including carbapenems, while the isolate remained susceptible to fluoroquinolones and tetracyclines. WGS identified the blaCRH-1 gene, likely contributing to the resistance phenotype.
CONCLUSION: This case emphasizes the importance of accurate species-level identification and AST in managing Chromobacterium infections, especially in immunocompromised or severely ill patients. Increased awareness of C. haemolyticum as a distinct clinical pathogen is essential, given its potential for misidentification and multidrug resistance.
DESIGN OR METHODS: Initial identification was performed using MALDI-TOF MS. Due to atypical phenotypic characteristics, including absence of violacein pigmentation and presence of β-hemolysis, whole-genome sequencing (WGS) was conducted for definitive species confirmation.
RESULT: Preliminary MALDI-TOF MS identification indicates that it is Chromobacterium violaceum; Definitive identification by whole-genome sequencing (WGS) confirmed C. haemolyticum. Antimicrobial susceptibility testing (AST) revealed high-level resistance to β-lactam antibiotics, including carbapenems, while the isolate remained susceptible to fluoroquinolones and tetracyclines. WGS identified the blaCRH-1 gene, likely contributing to the resistance phenotype.
CONCLUSION: This case emphasizes the importance of accurate species-level identification and AST in managing Chromobacterium infections, especially in immunocompromised or severely ill patients. Increased awareness of C. haemolyticum as a distinct clinical pathogen is essential, given its potential for misidentification and multidrug resistance.