Prenatal diagnosis · 2025
Clinical Implications of Low Cell-Free DNA Fetal Fraction in Non-Invasive Prenatal Testing: A Retrospective Cohort Study of 40,716 Pregnancies.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Yamamoto Kayono, Suzumori Nobuhiro, Miura Kiyonori, Yamada Takahiro, Kamei Yoshimasa, Sawai Hideaki, Hamanoue Haruka, Samura Osamu, Wada Seiji, Murotsuki Jun, Ichizuka Kiyotake, Komatsu Reina, Katagiri Yukiko, Morisaki Hiroko, Nakayama Setsuko, Mimura Kazuya, Matsubara Yuko, Okamoto Yoko, Maeda Kazuhisa, Yasuda Shun, Ida Akinori, Ito Mika, Hayakawa Hiromi, Fujiwara Arisa, Shirato Nahoko, Ishii Tatsuko, Sago Haruhiko, Sekizawa Akihiko
Аннотация
OBJECTIVE: This study aimed to investigate the association between fetal fraction (FF) on non-invasive prenatal testing (NIPT) and pregnancy-related complications using a large sample to support improved prenatal management.
METHODS: This retrospective cohort study included women with singleton pregnancies and negative NIPT results between January 2015 and March 2022 as part of the Japan Multicenter Study. Chi-square tests and binary logistic regression analyses were used to assess the association between FF and pregnancy-related complications.
RESULTS: A total of 40,716 responses were analyzed. No significant association was found between FF and placental abruption (χ2 (1) = 2.84, p = 0.09). Women in the low FF group (FF < 10.27%, < 25th percentile) had higher risks of fetal demise, adjusted OR = 1.79, 95% CI [1.31, 2.43]), preterm birth (adjusted OR = 1.63, 95% CI [1.30, 2.06]), fetal growth restriction (FGR) (adjusted OR = 1.50, 95% CI [1.10, 2.05]), and hypertensive disorders of pregnancy (HDP) (adjusted OR = 1.44, 95% CI [1.24, 1.66]). No significant differences were observed for gestational diabetes mellitus (GDM) (adjusted OR = 1.13, 95% CI [0.99, 1.30], p = 0.081).
CONCLUSION: Low FF on NIPT is associated with an increased risk of several pregnancy complications, highlighting the need for careful management.
METHODS: This retrospective cohort study included women with singleton pregnancies and negative NIPT results between January 2015 and March 2022 as part of the Japan Multicenter Study. Chi-square tests and binary logistic regression analyses were used to assess the association between FF and pregnancy-related complications.
RESULTS: A total of 40,716 responses were analyzed. No significant association was found between FF and placental abruption (χ2 (1) = 2.84, p = 0.09). Women in the low FF group (FF < 10.27%, < 25th percentile) had higher risks of fetal demise, adjusted OR = 1.79, 95% CI [1.31, 2.43]), preterm birth (adjusted OR = 1.63, 95% CI [1.30, 2.06]), fetal growth restriction (FGR) (adjusted OR = 1.50, 95% CI [1.10, 2.05]), and hypertensive disorders of pregnancy (HDP) (adjusted OR = 1.44, 95% CI [1.24, 1.66]). No significant differences were observed for gestational diabetes mellitus (GDM) (adjusted OR = 1.13, 95% CI [0.99, 1.30], p = 0.081).
CONCLUSION: Low FF on NIPT is associated with an increased risk of several pregnancy complications, highlighting the need for careful management.