American journal of dentistry · 2026
A randomized controlled clinical evaluation of anti-gingivitis and desensitizing efficacy of a newly developed toothpaste with zinc chloride and oriental herb extract.
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Moon Kyo Tae, Lim Jong Hyun, Oh Kyeonghee, Ha Wonho, Cho Min-Jewong, Lee Kyu-Hwan
Аннотация
PURPOSE: To evaluate the efficacy of a novel toothpaste formulation containing potassium phosphates, zinc chloride, and botanical extracts in managing periodontal conditions and dentin hypersensitivity.
METHODS: A single-center, double-blind, randomized controlled trial was conducted over 4 weeks with 97 participants aged 30 years and older, all experiencing dentin hypersensitivity. Participants were randomly assigned to three groups: a negative control group using standard toothpaste, an experimental group using the test toothpaste with conventional brushing, and another experimental group using the test toothpaste with topical application followed by brushing. Efficacy was assessed by measuring plaque deposition with the Patient Hygiene Performance (PHP) Index, gingival health with the Gingival Index (GI) and the Papillary, Marginal, and Attached gingival inflammation index, and dentin hypersensitivity with an electric pulp tester (EPT). Statistical analyses were performed using SPSS version 25.5, with analysis of variance and paired t-tests to compare results across groups and time points.
RESULTS: The topical application followed by brushing method (Group 3) demonstrated significantly greater efficacy in reducing dentin hypersensitivity, plaque accumulation, and gingival inflammation than both the control group and the conventional brushing group (Group 2). After 4 weeks, Group 3 demonstrated a 38.7% reduction in plaque index scores and a 50.8% reduction in GI scores, significantly outperforming the control group. For dentin hypersensitivity, Group 3 exhibited a 10.8% immediate desensitization effect, which was statistically significant compared with the control group. Questionnaire responses indicated higher satisfaction and perceived improvements in gingival health and sensitivity reduction in Group 3. These findings suggest that prolonging the contact time of active ingredients through delayed brushing enhances therapeutic outcomes for both dentin hypersensitivity and periodontal disease management.
CLINICAL SIGNIFICANCE: The modified application method of the newly developed toothpaste exhibited significantly greater reductions in plaque accumulation, gingival inflammation, and dentin hypersensitivity than the control and conventional brushing methods.
METHODS: A single-center, double-blind, randomized controlled trial was conducted over 4 weeks with 97 participants aged 30 years and older, all experiencing dentin hypersensitivity. Participants were randomly assigned to three groups: a negative control group using standard toothpaste, an experimental group using the test toothpaste with conventional brushing, and another experimental group using the test toothpaste with topical application followed by brushing. Efficacy was assessed by measuring plaque deposition with the Patient Hygiene Performance (PHP) Index, gingival health with the Gingival Index (GI) and the Papillary, Marginal, and Attached gingival inflammation index, and dentin hypersensitivity with an electric pulp tester (EPT). Statistical analyses were performed using SPSS version 25.5, with analysis of variance and paired t-tests to compare results across groups and time points.
RESULTS: The topical application followed by brushing method (Group 3) demonstrated significantly greater efficacy in reducing dentin hypersensitivity, plaque accumulation, and gingival inflammation than both the control group and the conventional brushing group (Group 2). After 4 weeks, Group 3 demonstrated a 38.7% reduction in plaque index scores and a 50.8% reduction in GI scores, significantly outperforming the control group. For dentin hypersensitivity, Group 3 exhibited a 10.8% immediate desensitization effect, which was statistically significant compared with the control group. Questionnaire responses indicated higher satisfaction and perceived improvements in gingival health and sensitivity reduction in Group 3. These findings suggest that prolonging the contact time of active ingredients through delayed brushing enhances therapeutic outcomes for both dentin hypersensitivity and periodontal disease management.
CLINICAL SIGNIFICANCE: The modified application method of the newly developed toothpaste exhibited significantly greater reductions in plaque accumulation, gingival inflammation, and dentin hypersensitivity than the control and conventional brushing methods.