Surgery today · 2026
A high ratio of visceral fat area to psoas muscle area predicts poor overall survival for esophageal cancer patients receiving definitive chemoradiotherapy.
СтатьяНазвание и аннотация: Перевод в очереди
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Sakai Makoto, Watanabe Takayoshi, Kuriyama Kengo, Tateno Kohei, Endo Mizuki, Nakazawa Nobuhiro, Ozawa Naoya, Komine Chika, Okada Takuhisa, Shiraishi Takuya, Kumakura Yuji, Kimura Akiharu, Sano Akihiko, Yokobori Takehiko, Nagai Kazue, Shirabe Ken, Saeki Hiroshi
Аннотация
PURPOSE: The ratio of visceral fat area to psoas muscle area (V/P ratio) is a computed tomography (CT)-derived marker of visceral adiposity relative to skeletal muscle mass. We evaluated the prognostic value of the V/P ratio in patients with esophageal cancer undergoing definitive chemoradiotherapy (CRT).
METHODS: The subjects of this retrospective analysis were 73 patients treated with definitive CRT between 2008 and 2017. The V/P ratio was measured at the third lumbar vertebra on CT. We performed multivariate Cox regression for overall survival (OS) and cancer-specific survival (CSS).
RESULTS: The median V/P ratio was 5.31 (interquartile range, 2.60-9.46). The visceral fat area (p < 0.001), body mass index (BMI) (p < 0.001), proportion of patients with a Charlson comorbidity index (CCI) ≥ 1 (p = 0.001), and age-adjusted CCI (p = 0.003) were significantly associated with the V/P ratio. After adjustment for clinical factors, the V/P ratio was found to be an independent prognostic factor for OS (HR 2.11 per 1-SD increase; 95% CI, 1.35-3.29; p = 0.001) and CSS (HR 2.49; 95% CI, 1.55-4.00; p < 0.001). The association persisted in non-obese patients.
CONCLUSION: The V/P ratio was associated with poor OS for esophageal cancer patients receiving definitive CRT, even for those who were not obese.
METHODS: The subjects of this retrospective analysis were 73 patients treated with definitive CRT between 2008 and 2017. The V/P ratio was measured at the third lumbar vertebra on CT. We performed multivariate Cox regression for overall survival (OS) and cancer-specific survival (CSS).
RESULTS: The median V/P ratio was 5.31 (interquartile range, 2.60-9.46). The visceral fat area (p < 0.001), body mass index (BMI) (p < 0.001), proportion of patients with a Charlson comorbidity index (CCI) ≥ 1 (p = 0.001), and age-adjusted CCI (p = 0.003) were significantly associated with the V/P ratio. After adjustment for clinical factors, the V/P ratio was found to be an independent prognostic factor for OS (HR 2.11 per 1-SD increase; 95% CI, 1.35-3.29; p = 0.001) and CSS (HR 2.49; 95% CI, 1.55-4.00; p < 0.001). The association persisted in non-obese patients.
CONCLUSION: The V/P ratio was associated with poor OS for esophageal cancer patients receiving definitive CRT, even for those who were not obese.