Analytica chimica acta · 2026
COF-Zincon dual signal amplification: A sensitive real-time electrochemical sensor for Zn2+ detection towards anxiety disorder diagnosis.
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Zou Honglong, Song Yonggui, Shao Jiaqi, Lai Bin, Fu Qinghui, Ai Zhifu, Liu Yali, Ping Yuhui, Su Dan, Zhang Youhui, Liang Huihui
Аннотация
BACKGROUND: In recent years, abnormal total zinc levels in serum have emerged as a robust indicator of anxiety disorder. However, measuring total zinc level requires sophisticated instrumentation and specialized personnel. Therefore, if the specific association between Zn2+ in serum and anxiety disorder can be elucidated, it is promising to develop rapid and convenient diagnostic methods for anxiety disorder. In the field of Zn2+ detection, Electrochemical detection has been investigated as a means to quantify Zn2+ with precision, rapidity and cost-effectiveness. Nevertheless, most current electrochemical systems lack specificity.
RESULTS: In this study, the relationship between anxiety disorder and serum Zn2+ level was first elucidated, with research finding indicating that anxiety in mice correlated with a marked decline in serum Zn2+ level. Subsequently, a sensitive and specific electrochemical sensor was developed to detect Zn2+ with outstanding detection performance for the diagnosis of anxiety disorder. In this sensor, covalent organic framework material (COFTp-Th) was utilized to load a substantial amount of gold nanoparticles (AuNPs) via Au-N bonds to obtain COFTp-Th-AuNPs material. AuNPs can enhance electrode catalysis and conductivity and served as a platform for subsequent material integration. Furthermore, a large quantity of Zincon reagent for specific recognition and detection of Zn2+ was loaded onto the AuNPs through Au-S and Au-N bonds to improve electrode specificity, resulting in the construction of the target electrode modified material of COFTp-Th-AuNPs-Zincon.
SIGNIFICANCE: Long-range ordered COFTp-Th can adsorb Zn2+ through its rich tetradentate coordination ONNO chelation sites formed by Tp and Th, representing the primary signal amplification. Simultaneously, the abundant Zincon in COFTp-Th-AuNPs-Zincon material with high affinity for the specific recognition and detection of Zn2+ contributed to secondary signal amplification. This approach leads to a significant improvement in the detection performance of Zn2+ and holds promise for providing robust support for the diagnosis and monitoring of anxiety disorder.
RESULTS: In this study, the relationship between anxiety disorder and serum Zn2+ level was first elucidated, with research finding indicating that anxiety in mice correlated with a marked decline in serum Zn2+ level. Subsequently, a sensitive and specific electrochemical sensor was developed to detect Zn2+ with outstanding detection performance for the diagnosis of anxiety disorder. In this sensor, covalent organic framework material (COFTp-Th) was utilized to load a substantial amount of gold nanoparticles (AuNPs) via Au-N bonds to obtain COFTp-Th-AuNPs material. AuNPs can enhance electrode catalysis and conductivity and served as a platform for subsequent material integration. Furthermore, a large quantity of Zincon reagent for specific recognition and detection of Zn2+ was loaded onto the AuNPs through Au-S and Au-N bonds to improve electrode specificity, resulting in the construction of the target electrode modified material of COFTp-Th-AuNPs-Zincon.
SIGNIFICANCE: Long-range ordered COFTp-Th can adsorb Zn2+ through its rich tetradentate coordination ONNO chelation sites formed by Tp and Th, representing the primary signal amplification. Simultaneously, the abundant Zincon in COFTp-Th-AuNPs-Zincon material with high affinity for the specific recognition and detection of Zn2+ contributed to secondary signal amplification. This approach leads to a significant improvement in the detection performance of Zn2+ and holds promise for providing robust support for the diagnosis and monitoring of anxiety disorder.