A successful pregnancy outcome using frozen testicular sperm from a chimeric infertile male with a 46, XX/46, XY karyotype: case report.

BACKGROUND

We report a very rare case of the successful delivery of a healthy infant fathered by an infertile chimera.

METHODS

ICSI was performed using frozen sperm. The karyotypes of peripheral lymphocytes were examined with a G-banding stain.

RESULTS

Chromosomal analysis prior to ICSI revealed a 46, XX [28]/46, XY [2] karyotype chimera. As an infant, the subject was diagnosed as a true hermaphrodite, and underwent a hysterectomy and oophorectomy. A small number of sperm were found in minced testicular tissue, and they were stored for ICSI.

CONCLUSION

To the best of our knowledge, this is the first case report of a successful pregnancy and delivery of a healthy infant fathered by an infertile chimera (46, XX/46, XY) following ICSI using frozen testicular sperm.