BMC pediatrics · 2025
Esophageal atresia with concomitant hypertrophic pyloric stenosis: a case series and literature review.
СтатьяОбзорКлинический случайНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Liu Zhaozhou, Wang An, Wang Dingding, Zhao Yong, Zhang Yanan, Li Shuangshuang, Liao Junmin, Hua Kaiyun, Gu Yichao, Sun Dayan, Huang Jinshi
Аннотация
BACKGROUND: Esophageal atresia (EA) with concomitant hypertrophic pyloric stenosis (HPS) is a rare condition, and its diagnosis can be challenging due to overlapping postoperative complications. Comprehensive clinical characterization remains limited.
METHODS: We retrospectively reviewed five patients with EA with concomitant HPS treated at our center between 2018 and 2025. A systematic literature search of PubMed, Embase, Web of Science, and CNKI identified 48 additional cases. Clinical features, timing of diagnosis, treatment strategies, and outcomes were analyzed.
RESULTS: Among 132 neonates with EA in our institution, five (3.8%) developed HPS. Four had Gross type C EA, and three were male. All underwent EA repair in the first week of life and later developed HPS, diagnosed at a median age of 45 days (range: 20-145). All patients underwent laparoscopic pyloromyotomy with uneventful recovery and were alive at a median follow-up of 50 months. Literature review revealed 48 reported cases, predominantly male (41/48) and Gross type C (42/48). Combined analysis of 53 patients showed HPS onset typically between 2 and 15 weeks, with a median age of 4 weeks (IQR: 2.5-6 weeks). Overall survival was 90.6%, with deaths mainly due to infection or severe associated anomalies.
CONCLUSIONS: HPS may coexist with EA, with an incidence of approximately 3.8%. It often presents later in the disease course. Its diagnosis can be delayed by postoperative complications or altered feeding. Long-term follow-up and multicenter studies are warranted.
METHODS: We retrospectively reviewed five patients with EA with concomitant HPS treated at our center between 2018 and 2025. A systematic literature search of PubMed, Embase, Web of Science, and CNKI identified 48 additional cases. Clinical features, timing of diagnosis, treatment strategies, and outcomes were analyzed.
RESULTS: Among 132 neonates with EA in our institution, five (3.8%) developed HPS. Four had Gross type C EA, and three were male. All underwent EA repair in the first week of life and later developed HPS, diagnosed at a median age of 45 days (range: 20-145). All patients underwent laparoscopic pyloromyotomy with uneventful recovery and were alive at a median follow-up of 50 months. Literature review revealed 48 reported cases, predominantly male (41/48) and Gross type C (42/48). Combined analysis of 53 patients showed HPS onset typically between 2 and 15 weeks, with a median age of 4 weeks (IQR: 2.5-6 weeks). Overall survival was 90.6%, with deaths mainly due to infection or severe associated anomalies.
CONCLUSIONS: HPS may coexist with EA, with an incidence of approximately 3.8%. It often presents later in the disease course. Its diagnosis can be delayed by postoperative complications or altered feeding. Long-term follow-up and multicenter studies are warranted.