European journal of obstetrics, gynecology, and reproductive biology · 2025
The impact of D-dimer monitoring combined with anticoagulation therapy on pregnancy outcomes and complications in recurrent spontaneous abortion: A case-control study.
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Ye Xi, Li Yongsheng, Zheng Chenmin
Аннотация
BACKGROUND: Recurrent abortion is often linked to coagulation abnormalities. Anticoagulation therapy combined with D-dimer monitoring may improve outcomes. To evaluate the effects of D-dimer monitoring combined with anticoagulation therapy on complications and pregnancy outcomes in recurrent abortion.
METHODS: From February 2019 to March 2021, 104 pregnant women with recurrent abortion were divided into a control group (n = 52, placebo) and an observation group (n = 52, D-dimer monitoring + anticoagulation). Uterine artery blood flow (S/D, PI, RI, diastolic notch) and coagulation parameters (PT, TT, APTT, FIB) were assessed before and after treatment. Pregnancy outcomes and complications were recorded.
RESULTS: After treatment, the observation group showed significantly improved uterine artery blood flow (lower S/D, PI, RI, diastolic notch; P < 0.05) and coagulation parameters (higher PT, TT, APTT; P < 0.05). Pregnancy loss and complications (preeclampsia, gestational hypertension, etc.) were significantly lower in the observation group (P < 0.05).
CONCLUSION: D-dimer monitoring combined with anticoagulation therapy improves uterine artery blood flow, balances coagulation, and reduces complications in recurrent abortion, enhancing pregnancy success rates. This approach is clinically valuable and warrants further application.
METHODS: From February 2019 to March 2021, 104 pregnant women with recurrent abortion were divided into a control group (n = 52, placebo) and an observation group (n = 52, D-dimer monitoring + anticoagulation). Uterine artery blood flow (S/D, PI, RI, diastolic notch) and coagulation parameters (PT, TT, APTT, FIB) were assessed before and after treatment. Pregnancy outcomes and complications were recorded.
RESULTS: After treatment, the observation group showed significantly improved uterine artery blood flow (lower S/D, PI, RI, diastolic notch; P < 0.05) and coagulation parameters (higher PT, TT, APTT; P < 0.05). Pregnancy loss and complications (preeclampsia, gestational hypertension, etc.) were significantly lower in the observation group (P < 0.05).
CONCLUSION: D-dimer monitoring combined with anticoagulation therapy improves uterine artery blood flow, balances coagulation, and reduces complications in recurrent abortion, enhancing pregnancy success rates. This approach is clinically valuable and warrants further application.