Cytotoxic lesion of the corpus callosum after gamma hydroxybutyrate withdrawal: a case report.

BACKGROUND

Gamma-hydroxybutyrate (GHB) is frequently misused for its sedative and euphoric effects. Abrupt cessation may result in severe withdrawal; however, neuroimaging correlates of withdrawal-related neurotoxicity remain poorly defined.

CASE PRESENTATION: A 33-year-old male developed acute delirium, visual hallucinations, and autonomic instability after abruptly discontinuing frequent and high-dose GHB use. Routine toxicology screening was negative. Brain MRI revealed a focal splenial cytotoxic lesion of the corpus callosum (CLOCCs). He was clinically diagnosed with sedative, hypnotic, or anxiolytic withdrawal; sedative-, hypnotic-, or anxiolytic-induced anxiety disorder; and sedative, hypnotic, or anxiolytic use disorder, severe. His symptoms rapidly resolved with supportive care, and he was discharged without neurological sequelae.

CONCLUSION

CLOCCs may represent an important radiological indicator of GHB withdrawal-related neurotoxicity.