Development (Cambridge, England) · 2022
TWIST1 interacts with β/δ-catenins during neural tube development and regulates fate transition in cranial neural crest cells.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Bertol Jessica W, Johnston Shelby, Ahmed Rabia, Xie Victoria K, Hubka Kelsea M, Cruz Lissette, Nitschke Larissa, Stetsiv Marta, Goering Jeremy P, Nistor Paul, Lowell Sally, Hoskens Hanne, Claes Peter, Weinberg Seth M, Saadi Irfan, Farach-Carson Mary C, Fakhouri Walid D
Аннотация
BACKGROUND: Self-collected vaginal sampling for human papillomavirus (HPV) DNA testing provides a promising alternative to physician-collected Pap smears, especially in low-resource settings. However, data on its acceptability and preferences among Filipino women remain limited. This study aimed to assess women's perceptions, experiences, willingness and preferences regarding self-collected vaginal sampling for HPV DNA testing compared with Pap smears.
METHODS: A cross-sectional study was conducted among 592 women. Participants underwent both physician-collected Pap smears and self-collected vaginal sampling for HPV DNA testing. Perceptions were measured using five-point Likert scale questionnaires before and after self-collection. Descriptive statistics were used, and paired and independent Wilcoxon tests were used to compare Likert responses. Willingness to undergo screening was analyzed with Cochran's Q and McNemar tests. Participants' reasons for their preferred screening method were categorized thematically and displayed in stacked bar charts.
RESULTS: Self-collection was generally viewed as painless, not uncomfortable, non-embarrassing, and easy and convenient. Acceptability significantly increased after participants performed self-collection (P < 0.001 for pain and discomfort). Compared with Pap smears, self-collection was seen as less embarrassing (P < 0.001), but rated as less easy (P = 0.01) and less convenient (P = 0.004). Most participants preferred physician-administered screening (84.8%) due to trust in medical expertise, and confidence in the procedure's accuracy, safety and cleanliness.
CONCLUSIONS: Self-collected vaginal sampling was highly acceptable, yet physician-collected screening remained the preferred method. Improving education, demonstrations, and support for self-collection may enhance the uptake of HPV DNA testing and broaden access to cervical cancer screening in the Philippines.
METHODS: A cross-sectional study was conducted among 592 women. Participants underwent both physician-collected Pap smears and self-collected vaginal sampling for HPV DNA testing. Perceptions were measured using five-point Likert scale questionnaires before and after self-collection. Descriptive statistics were used, and paired and independent Wilcoxon tests were used to compare Likert responses. Willingness to undergo screening was analyzed with Cochran's Q and McNemar tests. Participants' reasons for their preferred screening method were categorized thematically and displayed in stacked bar charts.
RESULTS: Self-collection was generally viewed as painless, not uncomfortable, non-embarrassing, and easy and convenient. Acceptability significantly increased after participants performed self-collection (P < 0.001 for pain and discomfort). Compared with Pap smears, self-collection was seen as less embarrassing (P < 0.001), but rated as less easy (P = 0.01) and less convenient (P = 0.004). Most participants preferred physician-administered screening (84.8%) due to trust in medical expertise, and confidence in the procedure's accuracy, safety and cleanliness.
CONCLUSIONS: Self-collected vaginal sampling was highly acceptable, yet physician-collected screening remained the preferred method. Improving education, demonstrations, and support for self-collection may enhance the uptake of HPV DNA testing and broaden access to cervical cancer screening in the Philippines.