FilaggrinHigh melanomas exhibit active FGFR and allergic signatures with impaired GNA14 and Th1 signatures.

Filaggrin gene (FLG/FLG2) product deregulations are associated with various allergic skin diseases, including but not limited to atopic dermatitis, alopecia areata, and ichthyosis vulgaris. However, the molecular immunological underpinnings of filaggrin phenotype manifestations are not completely understood. To gain insight into the underlying context, we classified the melanomas based on the filaggrin expression (filaggrinHigh/Low) and profiled the signaling context behind pruritic melanomas. We identified that the major signaling context changes behind filaggrinHigh melanomas are active FGFR signaling and impaired GNA14 and Th1 signatures, in addition to many genetic and immune changes that are associated with pruritus.