Retina (Philadelphia, Pa.) · 2026
FREQUENCY OF MISDIAGNOSES AND ASSOCIATED RISK FACTORS IN MACULAR TELANGIECTASIA TYPE 2.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Raming Kristin, Rodriguez Garcia Jose Luis, Steffens Nele, Nadal Jennifer, Herrmann Philipp, Holz Frank G, Pfau Kristina, Goerdt Lukas
Аннотация
PURPOSE: To analyze the frequency of misdiagnoses in macular telangiectasia type 2 (MacTel) and to investigate factors influencing the probability of receiving an incorrect diagnosis.
METHODS: A retrospective analysis of 288 patients with confirmed diagnosis of MacTel from the Natural History Observation Registry at the University Eye Hospital Bonn was performed. Patients were grouped as follows: correct diagnosis of MacTel, misdiagnosis, and incidental finding. Clinical and demographic data, including best-corrected visual acuity, symptoms, and prior treatments, were recorded. Misdiagnoses were categorized, and predictors were analyzed using mixed effect models.
RESULTS: Of 288 patients, 174 (60.4%) were correctly diagnosed, 103 (35.8%) were misdiagnosed, and 11 (3.8%) diagnosed incidentally. Misdiagnoses included macular hole (17.3%), maculopathy (12.5%), and AMD (12.5%). Mean age at symptom onset was 54.7 (±9.8) years; mean time to correct diagnosis was 38.5 ± 50.3 months, decreasing from 115 months (2000-2005) to 5.9 months (after 2020). Younger age at symptom onset reduced the probability of misdiagnosis (odds ratio 0.96, 95% CI: 0.94-0.98), subjective glare sensitivity increased misdiagnosis probability (odds ratio 2.01, 95% CI: 1.14-3.55).
CONCLUSION: Misdiagnoses of MacTel are common and may delay care. Improved awareness and imaging have shortened these delays. Early multimodal imaging and clinician education remain key to timely diagnosis and better management.
METHODS: A retrospective analysis of 288 patients with confirmed diagnosis of MacTel from the Natural History Observation Registry at the University Eye Hospital Bonn was performed. Patients were grouped as follows: correct diagnosis of MacTel, misdiagnosis, and incidental finding. Clinical and demographic data, including best-corrected visual acuity, symptoms, and prior treatments, were recorded. Misdiagnoses were categorized, and predictors were analyzed using mixed effect models.
RESULTS: Of 288 patients, 174 (60.4%) were correctly diagnosed, 103 (35.8%) were misdiagnosed, and 11 (3.8%) diagnosed incidentally. Misdiagnoses included macular hole (17.3%), maculopathy (12.5%), and AMD (12.5%). Mean age at symptom onset was 54.7 (±9.8) years; mean time to correct diagnosis was 38.5 ± 50.3 months, decreasing from 115 months (2000-2005) to 5.9 months (after 2020). Younger age at symptom onset reduced the probability of misdiagnosis (odds ratio 0.96, 95% CI: 0.94-0.98), subjective glare sensitivity increased misdiagnosis probability (odds ratio 2.01, 95% CI: 1.14-3.55).
CONCLUSION: Misdiagnoses of MacTel are common and may delay care. Improved awareness and imaging have shortened these delays. Early multimodal imaging and clinician education remain key to timely diagnosis and better management.