Congenital Non-Epidermolytic Ichthyosis in Two Littermate Mixed-Breed Yorkshire Terriers.

Congenital non-epidermolytic ichthyosis was diagnosed in two littermate mixed-breed Yorkshire terrier puppies. Histopathological results confirmed lamellar orthokeratosis; genetic testing for known mutations was negative. Topical treatment improved clinical signs, yet relapse occurred upon discontinuation. This case expands the breeds affected and emphasises the need for life-long management.