Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2014
Association of CDKN2A polymorphisms with the severity of cervical neoplasia in a Brazilian population.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Vargas-Torres Sandra Liliana, Portari Elyzabeth Avvad, Klumb Evandro Mendes, Guillobel Heloisa Carneiro da Rocha, de Camargo Maria José, Russomano Fábio Bastos, Macedo Jacyara Maria Brito
Аннотация
Variants of p16(INK4a) and p14(ARF), encoded by the CDKN2A locus, may respond differently to the presence of human papillomavirus (HPV). We investigated the potential association of two CDKN2A polymorphisms, 500C > G (rs11515) and 540C > T (rs3088440), with cervical neoplasia in patients with cervical lesions and healthy controls (n = 492). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), single-strand conformation polymorphism (SSCP) and/or DNA sequencing techniques were employed for genotyping. The 500G allele was found higher, whereas the 540T/T genotype was less frequent in patients with more severe lesions. The CDKN2A variants may have the potential to be markers for the management of patients with cervical neoplasia.
Предметные рубрики MeSH
AdolescentAdultAgedAged, 80 and overBrazilCase-Control StudiesCyclin-Dependent Kinase Inhibitor p16FemaleGenetic Association StudiesGenetic Predisposition to DiseaseHaplotypesHumansMiddle AgedPolymorphism, Restriction Fragment LengthPolymorphism, Single NucleotidePolymorphism, Single-Stranded ConformationalSequence Analysis, DNASeverity of Illness IndexUterine Cervical NeoplasmsYoung AdultUterine Cervical Dysplasia