Family history of stroke and cardiovascular diseases in early-onset cryptogenic ischaemic stroke.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Sihvo Maximilian C, Ylikotila Pauli, Zedde Marialuisa, Pascarella Rosario, Sarkanen Tomi, Jatužis Dalius, Ryliškienė Kristina, von Sarnowski Bettina, Licenik Radim, Ferdinand Phillip, Kõrv Janika, Kõrv Liisa, Pezzini Alessandro, Fonseca Ana Catarina, Paula André, Martínez-Sánchez Patricia, Yesilot Nilufer, Fromm Annette, Waje-Andreassen Ulrike, Redfors Petra, Jood Katarina, Huhtakangas Juha, Sairanen Tiina, Hedman Marja, Jäkälä Pekka, Ten Cate Hugo, Gerdts Eva, Lehto Mika, Sinisalo Juha, Kittner Steven J, Mitchell Braxton D, Lindgren Arne G, Ilinca Andreea, Putaala Jukka, Tomppo Liisa
Аннотация
METHODS: In this multicentre case-control study, we included eCIS patients aged 18-49 years and matched stroke-free controls. We analysed the association between FH of stroke, venous thromboembolism (VTE), coronary artery disease (CAD), aneurysms and eCIS using multivariable logistic regression, with a subgroup analysis stratifying patients by high-risk patent foramen ovale (HR-PFO).
RESULTS: We enrolled 508 eCIS patients (182 [36%] with HR-PFO) and 520 controls. Compared with controls, patients more frequently reported FH of stroke among first-degree relatives (FDR) (20% vs. 14%, P = .01) and grandparents (47% vs. 39%, P = .01), FH of early-onset stroke among FDR (5% vs. 2%, P = .01) and FH of early-onset VTE among FDR (5% vs. 2%, P = .003). In adjusted analyses, eCIS was associated with FH of stroke among FDR (OR 1.50; 95% CI, 1.04-2.16) and grandparents (1.50; 1.12-1.99), with FH of early-onset stroke among FDR (2.36; 1.11-5.04); and with FH of early-onset VTE among FDR (3.45; 1.47-8.13). eCIS was also associated with FH of VTE among FDR (1.80, 1.09-2.98) in the presence of HR-PFO. FH of CAD or aneurysms was not associated with eCIS.
CONCLUSION: FH of stroke and VTE, particularly early-onset events and in the presence of HR-PFO, are associated with eCIS. These findings support familial predisposition and highlight prothrombotic mechanisms in eCIS.
CLINICAL TRIAL REGISTRATION: www.clinicaltrials.gov/study/NCT01934725.