What should the urologist know on the management of kidney cancer in patients with Von Hippel-Lindau syndrome? Recommendations of the European Association of Urology (EAU) Young Academic Urologists (YAU) Renal Cancer Working Group.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Erdem Selcuk, Amparore Daniele, Re Chiara, Verep Samed, Capitanio Umberto, Larcher Alessandro, Roussel Eduard, Klatte Tobias, Bertolo Riccardo, Muselaers Stijn, Pavan Nicola, Kara Onder, Ingels Alexandre, Pecoraro Angela, Marchioni Michele, Pandolfo Savio Domenico, Diana Pietro, Carbonara Umberto, Mollica Veronica, Warren Hannah, Borregales Leonardo, Marandino Laura, Sharma Gopal, Caliò Anna, Wu Zhenjie, Lovati Luca Alberto, Ciccarese Chiara, Margue Gaëlle, Francolini Giulio, Flippot Ronan, Leung David Kawai, Mjaess Georges, Rosiello Giuseppe, Mir Maria Carme, Palumbo Carlotta, Campi Riccardo, EAU-YAU Renal Cancer Working Group
Аннотация
METHODS: The articles indexed between 1977 and 2025 in PubMed was searched. Only articles in English were included.
RESULTS: Renal cysts are quite common in VHL patients and these cysts predispose for RCC. VHL patients are characterized with early-onset, multifocal and/or bilateral, recurrent and clear cell subtype RCC. Patients should be monitored at regular intervals. Due to recurrent characteristics of RCC, nephron-sparing surgeries should be prioritized with the aim of life-long kidney function preservation, whenever it is feasible. Focal treatments should be considered in patients for whom surgery is not suitable. In addition, belzutifan treatment has shown promising results in selected patients.
CONCLUSION: In VHL patients with RCC, kidney function should be preserved whenever possible to ensure a long and high-quality life. Since these patients may develop lesions in other organs beyond kidney, surveillance with multidisciplinary approach in tertiary centers should be recommended.