Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
Management of glioblastoma in the elderly.
СтатьяНазвание и аннотация: Перевод в очереди
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Morilla Idoia, Caviedes Edinson, Gironés Sarrió Regina, López de San Vicente Hernández Borja, Luque Caro Natalia, Del Barco Sonia, Cano Juana M, Vaz-Salgado María Ángeles
Аннотация
Glioblastoma is the most aggressive and common malignant primary brain tumor among adults. Due to its aggressiveness, GBM entails a short median overall survival and fatal outcomes. Incidence notably increases with age, 50% of patients being diagnosed at the age of 65 or older. Given that cognitive loss is commonly confused with age-related cognitive impairment, delays in diagnosis are frequent. Furthermore, the elderly are a vulnerable group, commonly having poorer functional status, more comorbidities, and reduced tolerance to intensive treatments. Therefore, clinical and therapeutic implications should be considered within a multidisciplinary approach. The aim of the present study was to review the current knowledge on the management of glioblastoma in the elderly population (≥ 65 years).