Discover oncology · 2026
Atypical cortical presentation of anti-Ri paraneoplastic encephalitis mimicking tumor.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Lee Seolah
Аннотация
PURPOSE: This report expands the known clinical phenotype of anti-Ri (ANNA-2)-associated paraneoplastic syndrome to include isolated neocortical involvement.
METHODS AND RESULTS: We report the case of a 54-year-old woman who presented with transient apraxia, confusion, and headache. Brain MRI revealed a tumor-like lesion in the left frontal cortex. Stereotactic brain biopsy showed inflammatory changes without evidence of malignancy. Serum testing was strongly positive for anti-Ri antibodies, and systemic workup identified breast cancer with axillary lymph node metastasis. The patient received breast cancer surgery and chemotherapy alongside high-dose steroid pulse therapy and four weekly doses of rituximab, resulting in marked resolution of the cortical lesion.
CONCLUSION: While current PNS-Care diagnostic criteria enabled a definitive diagnosis, further investigation is warranted to elucidate the underlying pathomechanism of cortical involvement in anti-Ri paraneoplastic neurological syndrome.
METHODS AND RESULTS: We report the case of a 54-year-old woman who presented with transient apraxia, confusion, and headache. Brain MRI revealed a tumor-like lesion in the left frontal cortex. Stereotactic brain biopsy showed inflammatory changes without evidence of malignancy. Serum testing was strongly positive for anti-Ri antibodies, and systemic workup identified breast cancer with axillary lymph node metastasis. The patient received breast cancer surgery and chemotherapy alongside high-dose steroid pulse therapy and four weekly doses of rituximab, resulting in marked resolution of the cortical lesion.
CONCLUSION: While current PNS-Care diagnostic criteria enabled a definitive diagnosis, further investigation is warranted to elucidate the underlying pathomechanism of cortical involvement in anti-Ri paraneoplastic neurological syndrome.