American journal of ophthalmology case reports · 2025
Histopathological changes in the trabecular meshwork in primary congenital glaucoma.
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Rao Aparna
Аннотация
PURPOSE: To evaluate the morphological changes in the ex-vivo trabecular meshwork TM specimens from patients with primary congenital glaucoma.
METHODS: Five trabecular meshwork (TM) specimens obtained after microincisional trabeculectomy from 4 patients with primary congenital glaucoma (mean age) were analyzed using hematological and eosin staining.
RESULTS: The trabecular meshwork in PCG showed an expansion of the juxtacanalicular and corneoscleral meshwork regions with increased cellularity, thickened TM beams, prominent spindle-shaped nuclei suggesting epithelial mesenchymal transformation predominantly and two morphologically distinct zones of the juxtacanalicular region.
CONCLUSIONS: Increased cellularity, zonal expansion and mesenchymal changes in specific TM regions suggest aberrant differentiation and differential dysgenesis of different TM regions in PCG.
METHODS: Five trabecular meshwork (TM) specimens obtained after microincisional trabeculectomy from 4 patients with primary congenital glaucoma (mean age) were analyzed using hematological and eosin staining.
RESULTS: The trabecular meshwork in PCG showed an expansion of the juxtacanalicular and corneoscleral meshwork regions with increased cellularity, thickened TM beams, prominent spindle-shaped nuclei suggesting epithelial mesenchymal transformation predominantly and two morphologically distinct zones of the juxtacanalicular region.
CONCLUSIONS: Increased cellularity, zonal expansion and mesenchymal changes in specific TM regions suggest aberrant differentiation and differential dysgenesis of different TM regions in PCG.