American heart journal · 2026
Cardiorespiratory fitness in children with surgically corrected congenital heart disease: Exercise testing profiles and biventricular function.
СтатьяНазвание и аннотация: Перевод в очереди
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Haas Stijn D, van der Hulst Annelies E, Widyanti Ari P, van Schuppen Joost, Oosterlaan Jaap, van den Aardweg Joost G, Ten Harkel Arend D J, Kuipers Irene M, Blom Nico A
Аннотация
AIMS: Children with surgically corrected congenital heart disease (CHD) often exhibit reduced cardiorespiratory fitness, reflected by impaired maximal oxygen uptake (̇VO₂max). Although exercise limitation is multifactorial, the relative contributions of cardiovascular, ventilatory, and gas exchange abnormalities remain unclear. This study aims to characterize exercise impairments in children with CHD using cardiopulmonary exercise testing (CPET) and cardiac imaging.
METHODS: Children with surgically corrected biventricular CHD were prospectively recruited. CPET parameters were expressed as percentages of predicted (%pred) for age and sex, and biventricular function was evaluated by echocardiography and cardiac magnetic resonance imaging. Regression analyses examined associations between ̇VO₂max, exercise parameters, and imaging-derived cardiac function.
RESULTS: In total, 100 consecutive children with CHD were included. ̇VO₂max (73.9%pred ± 14.2%pred) and anaerobic threshold (̇VO₂AT; 74.7%pred ± 16.6%pred) showed the greatest deviation from normal. CPET demonstrated cardiovascular (oxygen pulse, maximal heart rate), ventilatory (maximal ventilation), and gas exchange impairments (ventilatory inefficiency). Imaging showed reduced systolic function, particularly left ventricular global longitudinal strain (-17.5% ± 2.5%) and tricuspid annular plane systolic excursion (13.1 mm, interquartile range 11.0 to 15.4). ̇VO₂AT, maximal heart rate, global longitudinal strain, and tricuspid annular plane systolic excursion independently predicted ̇VO₂max (R² = 68.1%; P < .001), with ̇VO₂AT the strongest predictor.
CONCLUSIONS: Reduced cardiorespiratory fitness in children with surgically corrected CHD encompasses impaired cardiovascular, ventilatory, and gas exchange responses to exercise. Early anaerobic threshold, chronotropic incompetence, and subclinical systolic dysfunction on imaging are associated with reduced maximal exercise capacity, indicating contributions from both cardiac dysfunction and deconditioning. Integrating imaging with CPET may improve differentiation between cardiac and noncardiac contributors to exercise limitation.
METHODS: Children with surgically corrected biventricular CHD were prospectively recruited. CPET parameters were expressed as percentages of predicted (%pred) for age and sex, and biventricular function was evaluated by echocardiography and cardiac magnetic resonance imaging. Regression analyses examined associations between ̇VO₂max, exercise parameters, and imaging-derived cardiac function.
RESULTS: In total, 100 consecutive children with CHD were included. ̇VO₂max (73.9%pred ± 14.2%pred) and anaerobic threshold (̇VO₂AT; 74.7%pred ± 16.6%pred) showed the greatest deviation from normal. CPET demonstrated cardiovascular (oxygen pulse, maximal heart rate), ventilatory (maximal ventilation), and gas exchange impairments (ventilatory inefficiency). Imaging showed reduced systolic function, particularly left ventricular global longitudinal strain (-17.5% ± 2.5%) and tricuspid annular plane systolic excursion (13.1 mm, interquartile range 11.0 to 15.4). ̇VO₂AT, maximal heart rate, global longitudinal strain, and tricuspid annular plane systolic excursion independently predicted ̇VO₂max (R² = 68.1%; P < .001), with ̇VO₂AT the strongest predictor.
CONCLUSIONS: Reduced cardiorespiratory fitness in children with surgically corrected CHD encompasses impaired cardiovascular, ventilatory, and gas exchange responses to exercise. Early anaerobic threshold, chronotropic incompetence, and subclinical systolic dysfunction on imaging are associated with reduced maximal exercise capacity, indicating contributions from both cardiac dysfunction and deconditioning. Integrating imaging with CPET may improve differentiation between cardiac and noncardiac contributors to exercise limitation.