Effects of carbetocin combined with ergometrine maleate on blood loss and coagulation function of puerperae with postpartum haemorrhage.

OBJECTIVE

To determine the effects of carbetocin combined with ergometrine maleate on blood loss and coagulation function of puerperae with postpartum haemorrhage (PH).

METHODS

In this retrospective study, the clinical data of 102 puerperae with PH treated in Harbin Red Cross Central Hospital from March 2019 to February 2022 were analyzed. Among them, 45 puerperae treated with carbetocin alone were assigned to the control group, and the other 57 treated with carbetocin combined ergometrine maleate were assigned to the observation group. After treatment, the blood loss, hemostasis time, changes of coagulation function and hemodynamic indexes, efficacy and incidence of adverse reactions were compared between the two groups.

RESULTS

The blood loss within 2 h and 24 h after treatment and hemostasis time of the observation group were greatly lower than those of the control group (P<0.05). After therapy, the coagulation function-associated indexes (fibrinogen (FIB), prothrombin time (PT), and activated partial thromboplastin time (APTT)) of the two groups were all improved, with greatly better coagulation function-associated indexes in the observation group than those in the control group (all P<0.05). After therapy, the observation group showed notably lower hemodynamic indexes (hear rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP)) than the control group (all P<0.05). Additionally, the observation group yielded a greatly higher effective treatment rate than the control group (P<0.05), and the incidence of adverse reactions in both groups was low, without significant difference (P>0.05).

CONCLUSION

Ergometrine maleate combined with carbetocin can deliver favorable efficacy on PH, because it can effectively reduce the amount and duration of PH, improve the coagulation state of the body, and maintain the stability of hemodynamics, without increasing adverse reactions. Therefore, it is of high application value.