Fertility and sterility · 2006
Preliminary prospective study of the endocrinology of conception cycles and early pregnancy in women with antiphospholipid syndrome treated with low molecular weight heparin.
Сравнительное исследованиеКонтролируемое клиническое исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Prakash Alka, Laird Susan, Li Tin C, Ledger William L
Аннотация
OBJECTIVE: To examine whether there were any differences in the endocrinological profiles during conception cycle and early pregnancy between a control group and women with a history of recurrent miscarriage that was caused by antiphospholipid syndrome and that was treated with aspirin and low molecular weight heparin.
DESIGN: Prospective observational study.
SETTING: Recurrent Miscarriage Clinic, Department of Obstetrics and Gynaecology in a tertiary care centre.
PATIENT(S): Five women with recurrent pregnancy loss were recruited as cases, whereas another five women having natural cycle donor insemination were used as control.
INTERVENTION(S): Serial measurement of serum beta-hCG, activin A, and inhibin A was performed from postovulatory day 12 until 11 weeks of gestation.
MAIN OUTCOME MEASURE(S): Comparison of levels of beta-hCG, activin A, and inhibin A at the time of conception onwards till 11 weeks in the two groups.
RESULT(S): There were no significant differences between the two groups.
CONCLUSION(S): There does not appear to be any obvious endocrinological alteration in the conception cycle of women with antiphospholipid syndrome compared with a control group. Furthermore, the initiation of heparin does not produce a significant change in activin A and inhibin A levels.
DESIGN: Prospective observational study.
SETTING: Recurrent Miscarriage Clinic, Department of Obstetrics and Gynaecology in a tertiary care centre.
PATIENT(S): Five women with recurrent pregnancy loss were recruited as cases, whereas another five women having natural cycle donor insemination were used as control.
INTERVENTION(S): Serial measurement of serum beta-hCG, activin A, and inhibin A was performed from postovulatory day 12 until 11 weeks of gestation.
MAIN OUTCOME MEASURE(S): Comparison of levels of beta-hCG, activin A, and inhibin A at the time of conception onwards till 11 weeks in the two groups.
RESULT(S): There were no significant differences between the two groups.
CONCLUSION(S): There does not appear to be any obvious endocrinological alteration in the conception cycle of women with antiphospholipid syndrome compared with a control group. Furthermore, the initiation of heparin does not produce a significant change in activin A and inhibin A levels.