Immunology letters · 2026
Influences of age and sex on allergic symptoms in food allergy model mice.
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Morii Hikari, Haraoka Noriaki, Seki Shimpei, Sugimoto Yukio
Аннотация
BACKGROND: There are few studies on age and sex differences in food allergies, and many aspects remain unclear. In this study, we investigated the influences of age and sex differences in a food allergy model.
METHODS: Mice were sensitized with OVA. Mice were observed for scratching behavior, sneezing, and nasal rubbing induced by oral administration of OVA. In addition, histamine sensitivity was evaluated by administering histamine intradermally and nasally. Additionally, antigen-specific IgE antibodies were measured.
RESULTS: Scratching behavior, sneezing and nasal rubbing in food allergy decreased with age in both male and female mice. Nasal rubbing behavior increased in male mice compared with female mice in young mice, but decreased with age in both male and female mice. Furthermore, sneezing and nasal rubbing responses were increased in male mice compared with female mice. On the other hand, the antigen-specific IgE antibody decreased with age in both male and female mice, but increased in male mice compared to female mice. Furthermore, histamine-induced rhinitis symptoms also decreased with age.
CONCLUSIONS: In food allergy model, it was found that rhinitis symptoms and antigen-specific IgE antibody levels decreased with age. It was also found that histamine-induced rhinitis symptoms decreased with age. Additionally, food allergy symptoms were found to be increased in male compared to female at young age. On the other hand, it was revealed that there was almost no sex difference in the symptoms of food allergy in aged mice.
METHODS: Mice were sensitized with OVA. Mice were observed for scratching behavior, sneezing, and nasal rubbing induced by oral administration of OVA. In addition, histamine sensitivity was evaluated by administering histamine intradermally and nasally. Additionally, antigen-specific IgE antibodies were measured.
RESULTS: Scratching behavior, sneezing and nasal rubbing in food allergy decreased with age in both male and female mice. Nasal rubbing behavior increased in male mice compared with female mice in young mice, but decreased with age in both male and female mice. Furthermore, sneezing and nasal rubbing responses were increased in male mice compared with female mice. On the other hand, the antigen-specific IgE antibody decreased with age in both male and female mice, but increased in male mice compared to female mice. Furthermore, histamine-induced rhinitis symptoms also decreased with age.
CONCLUSIONS: In food allergy model, it was found that rhinitis symptoms and antigen-specific IgE antibody levels decreased with age. It was also found that histamine-induced rhinitis symptoms decreased with age. Additionally, food allergy symptoms were found to be increased in male compared to female at young age. On the other hand, it was revealed that there was almost no sex difference in the symptoms of food allergy in aged mice.