Cognitive function instrument-based anosognosia to predict amyloid status.

Anosognosia, a lack of self-awareness regarding cognitive dysfunction, often accompanies the progression of Alzheimer's disease (AD) pathology. This study explored the relationship between AD pathology and anosognosia measured by discrepancies in Cognitive Function Instrument (CFI) scores, as rated by participants and their study partners (SP). Using mixed-effects models on non-demented participant data, the results revealed that lower self-reported CFI score compared to SP ratings was significantly associated with positive amyloid PET results (odds ratio 1.081 per-1 decrease in ΔCFI). Our findings suggest that CFI-based anosognosia could serve as a potential predictor of positive amyloid PET status.