Stem cell research · 2025
Generation of two isogenic induced pluripotent stem cell lines derived from a Hispanic individual with Alzheimer's Disease and mosaic for loss of the Y chromosome.
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Cukier Holly N, DeRosa Brooke A, Coombs Lauren E, Tang Eugene, Leyva Denise R, Lazzaro Ainnara R, Gu Esther, Dykxhoorn Derek M, Haines Jonathan L, Pericak-Vance Margaret A, Song Yeunjoo E, Bush William S, Griswold Anthony J
Аннотация
Mosaic loss of the Y chromosome (LOY) is a somatic phenomenon that occurs in males as they age (Jacobs, 1963; Forsberg, 2017; Danielsson, 2020) and is associated with an elevated risk of developing numerous diseases, including Alzheimer's Disease (AD) (Dumanski, 2016; Palmer, et al., 2022; Garcia-Gonzalez, 2023), cancer (Holmes, 1985; Loftfield, 2018), diabetes (Loftfield, 2018), age related macular degeneration (Grassmann, 2019), and autoimmune disease (Persani, 2012; Lleo, 2013). The induced pluripotent cell lines (iPSCs) UMi050-A and UMi050-B were derived from a Hispanic male with loss of the Y chromosome in his blood and diagnosed with AD. This isogenic pair of lines with and without a Y chromosome is a unique resource to delve into the mechanism of LOY and its relationship to AD risk.