JACC. Case reports · 2025
Surgical Aortic Valve Replacement Combined With Coronary Artery Bypass Grafting in a Patient With Progeria.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Anquetil Simon, Bignon Mathieu, Belli Emré, Labombarda Fabien
Аннотация
BACKGROUND: Calcific aortic stenosis is increasingly recognized as a major determinant of mortality in the aging subset of patients with the ultra-rare Hutchinson-Gilford progeria syndrome (HGPS), particularly as survival improves with lonafarnib therapy. However, the optimal treatment strategy for severe aortic stenosis in this population remains undefined.
CASE SUMMARY: We report the first successful case of combined surgical aortic valve replacement and coronary artery bypass grafting in a severely symptomatic 21-year-old man with HGPS, severe calcific aortic stenosis, and coronary artery disease.
DISCUSSION: Despite anatomical and procedural challenges, surgical valve replacement represents a reasonable treatment option in patients with HGPS when transcatheter or alternative approaches are not feasible. A multidisciplinary approach is essential to optimize outcomes in this high-risk population.
TAKE-HOME MESSAGE: Surgical aortic valve replacement may be considered among the potential treatment options for selected patients with HGPS.
CASE SUMMARY: We report the first successful case of combined surgical aortic valve replacement and coronary artery bypass grafting in a severely symptomatic 21-year-old man with HGPS, severe calcific aortic stenosis, and coronary artery disease.
DISCUSSION: Despite anatomical and procedural challenges, surgical valve replacement represents a reasonable treatment option in patients with HGPS when transcatheter or alternative approaches are not feasible. A multidisciplinary approach is essential to optimize outcomes in this high-risk population.
TAKE-HOME MESSAGE: Surgical aortic valve replacement may be considered among the potential treatment options for selected patients with HGPS.