The Journal of thoracic and cardiovascular surgery · 2026
Long-term echocardiographic and clinical outcomes after aortic root replacement in patients with Marfan syndrome.
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Murrieta-Álvarez Iván, Miller D Craig, LeMaire Scott A, Connolly Heidy M, Green Susan Y, Sundt Thoralf M, Desai Nimesh D, Girardi Leonard N, Schaff Hartzell V, Dietz Harry C, Moon Marc R, Coselli Joseph S, Aortic Valve Operative Outcomes in Marfan Patients Study Group (AVOMP)
Аннотация
OBJECTIVE: We compared longitudinal echocardiographic data between patients with Marfan syndrome who underwent aortic valve-sparing (AVS) and aortic valve-replacing (AVR) aortic root replacement procedures.
METHODS: Of 316 patients enrolled at 19 sites in 5 countries, 239 (75%) were treated with AVS and 77 (25%) with AVR. Transthoracic echocardiograms were collected at postoperative years 1, 3, 5, 7, 10, 12, 14, 16, 18, and 20. Mixed-effects models were used to evaluate echocardiographic changes over time. Inverse probability-weighted Cox regression models were used to compare the risk of persistent postoperative aortic regurgitation (AR) grade ≥2+ and AV reintervention between AVS and AVR.
RESULTS: Echocardiographic studies showed greater AR grades in the AVS group during early-to-midterm follow-up (P < .001). The AVS group also had somewhat larger annular size (P < .001) and left ventricular end-systolic (P < .001) and end-diastolic (P = .003) diameters. AV mean gradient, AV systolic velocity, left ventricular ejection fraction, and sinus of Valsalva diameter did not have significantly different trajectories over time between the AVS and AVR groups. Although the AVS and AVR groups did not differ in overall survival (P = .2) or AV reintervention rates (P = .2), persistent AR grade ≥2+ was associated with AV reintervention (P = .01).
CONCLUSIONS: Although patients with Marfan syndrome who underwent AVS had greater annular dilatation and greater AR grades than patients who underwent AVR, the likelihood of AV reintervention and death was similar between the groups.
METHODS: Of 316 patients enrolled at 19 sites in 5 countries, 239 (75%) were treated with AVS and 77 (25%) with AVR. Transthoracic echocardiograms were collected at postoperative years 1, 3, 5, 7, 10, 12, 14, 16, 18, and 20. Mixed-effects models were used to evaluate echocardiographic changes over time. Inverse probability-weighted Cox regression models were used to compare the risk of persistent postoperative aortic regurgitation (AR) grade ≥2+ and AV reintervention between AVS and AVR.
RESULTS: Echocardiographic studies showed greater AR grades in the AVS group during early-to-midterm follow-up (P < .001). The AVS group also had somewhat larger annular size (P < .001) and left ventricular end-systolic (P < .001) and end-diastolic (P = .003) diameters. AV mean gradient, AV systolic velocity, left ventricular ejection fraction, and sinus of Valsalva diameter did not have significantly different trajectories over time between the AVS and AVR groups. Although the AVS and AVR groups did not differ in overall survival (P = .2) or AV reintervention rates (P = .2), persistent AR grade ≥2+ was associated with AV reintervention (P = .01).
CONCLUSIONS: Although patients with Marfan syndrome who underwent AVS had greater annular dilatation and greater AR grades than patients who underwent AVR, the likelihood of AV reintervention and death was similar between the groups.