Health technology assessment (Winchester, England) · 2026
Relative and bedside nurse assessment of comfort and communication during propofol, dexmedetomidine, or clonidine-based sedation: pre-planned analysis within the A2B RCT.
СтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Walsh Timothy S, Parker Richard A, Aitken Leanne M, McKenzie Cathrine A, Glen Robert, Weir Christopher J
Аннотация
BACKGROUND: Optimising comfort and ability to communicate for mechanically ventilated intensive care unit patients is a priority for clinicians, intensive care unit patients and their relatives. Current usual care is propofol-based sedation plus an opioid analgesic. The alpha2-agonists dexmedetomidine and clonidine are potential alternative sedatives.
OBJECTIVE(S): To explore whether nurses and relatives perceive patients sedated with dexmedetomidine and/or clonidine appear more awake, comfortable and co-operative than patients receiving only propofol-based sedation.
DESIGN AND METHODS: Substudy within an open-label, three-arm trial.
SETTING AND PARTICIPANTS: Forty-one intensive care units in the United Kingdom. One thousand four hundred and thirty-seven adults receiving propofol ± opioid for sedation-analgesia within 48 hours of starting mechanical ventilation, expected to require ≥ 48 total hours of mechanical ventilation.
INTERVENTIONS: Light sedation was targeted in all patients unless clinicians requested deeper sedation. In intervention groups, algorithms promoted alpha2-agonist up-titration and propofol down-titration, followed by sedation primarily with allocated alpha2-agonist. Usual care was propofol-based sedation. Intervention continued until patients were successfully extubated (primary outcome), or other pre-defined end points.
OUTCOMES: For each 12-hour care period, nurses responded to two 'yes/no' questions: is the patient able to communicate pain? Is the patient able to co-operate with care? When the patients' personal legal representative visited, they were asked for 'yes/no' responses to three questions: does the patient appear awake? Does the patient appear comfortable? Does the visitor feel they can communicate with the patient? Intervention versus propofol group responses were compared fitting a generalised linear mixed model, with results expressed as odds ratios (95% confidence intervals); odds ratios > 1 indicated greater probability of a 'yes' response.
RESULTS: Nurse responses were available for > 90% of trial patients [mean (standard deviation) 12 (12) care periods per patient]. Comparing dexmedetomidine versus propofol groups, the odds ratio for a 'yes' response to 'communicate pain' was 1.38 (95% confidence interval 1.08 to 1.75), and for clonidine versus propofol, it was 1.13 (0.89 to 1.43). For 'co-operate with care' comparing dexmedetomidine versus propofol groups, the odds ratio was 1.14 (95% confidence interval 0.98 to 1.32), and for clonidine versus propofol, it was 0.96 (95% confidence interval 0.83 to 1.12). Relative responses were available for 32-34% of trial patients across groups [mean (standard deviation) 3 (3) days per patient]. For the 'appear awake' question, the dexmedetomidine versus propofol group odds ratio was 1.48 (95% confidence interval 1.04 to 2.10), and for clonidine versus propofol, it was 1.35 (95% confidence interval 0.95 to 1.91). For 'appear comfortable', the dexmedetomidine versus propofol group odds ratio was 0.64 (95% confidence interval 0.38 to 1.09), and for clonidine versus propofol, it was 0.78 (95% confidence interval 0.45 to 1.34). For the 'feel they can communicate' comparison, the dexmedetomidine versus propofol group odds ratio was 1.00 (95% confidence interval 0.68 to 1.47), and for clonidine versus propofol, it was 1.05 (95% confidence interval 0.71 to 1.54).
LIMITATIONS: Interventions were unblinded, with risk of bias; missing data may not have been at random.
CONCLUSIONS: Nurses perceived patients receiving dexmedetomidine-based sedation could better communicate pain than with propofol-based sedation, and relatives perceived patients appeared more awake. No differences for the other questions were found, or for the clonidine versus propofol comparisons, although some uncertainty remains due to the wide confidence intervals.
FUTURE WORK: Additional mixed-methods research of sedation quality with different agents from staff and relative perspectives.
FUNDING: This article presents independent research funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme as award number 16/93/01.
OBJECTIVE(S): To explore whether nurses and relatives perceive patients sedated with dexmedetomidine and/or clonidine appear more awake, comfortable and co-operative than patients receiving only propofol-based sedation.
DESIGN AND METHODS: Substudy within an open-label, three-arm trial.
SETTING AND PARTICIPANTS: Forty-one intensive care units in the United Kingdom. One thousand four hundred and thirty-seven adults receiving propofol ± opioid for sedation-analgesia within 48 hours of starting mechanical ventilation, expected to require ≥ 48 total hours of mechanical ventilation.
INTERVENTIONS: Light sedation was targeted in all patients unless clinicians requested deeper sedation. In intervention groups, algorithms promoted alpha2-agonist up-titration and propofol down-titration, followed by sedation primarily with allocated alpha2-agonist. Usual care was propofol-based sedation. Intervention continued until patients were successfully extubated (primary outcome), or other pre-defined end points.
OUTCOMES: For each 12-hour care period, nurses responded to two 'yes/no' questions: is the patient able to communicate pain? Is the patient able to co-operate with care? When the patients' personal legal representative visited, they were asked for 'yes/no' responses to three questions: does the patient appear awake? Does the patient appear comfortable? Does the visitor feel they can communicate with the patient? Intervention versus propofol group responses were compared fitting a generalised linear mixed model, with results expressed as odds ratios (95% confidence intervals); odds ratios > 1 indicated greater probability of a 'yes' response.
RESULTS: Nurse responses were available for > 90% of trial patients [mean (standard deviation) 12 (12) care periods per patient]. Comparing dexmedetomidine versus propofol groups, the odds ratio for a 'yes' response to 'communicate pain' was 1.38 (95% confidence interval 1.08 to 1.75), and for clonidine versus propofol, it was 1.13 (0.89 to 1.43). For 'co-operate with care' comparing dexmedetomidine versus propofol groups, the odds ratio was 1.14 (95% confidence interval 0.98 to 1.32), and for clonidine versus propofol, it was 0.96 (95% confidence interval 0.83 to 1.12). Relative responses were available for 32-34% of trial patients across groups [mean (standard deviation) 3 (3) days per patient]. For the 'appear awake' question, the dexmedetomidine versus propofol group odds ratio was 1.48 (95% confidence interval 1.04 to 2.10), and for clonidine versus propofol, it was 1.35 (95% confidence interval 0.95 to 1.91). For 'appear comfortable', the dexmedetomidine versus propofol group odds ratio was 0.64 (95% confidence interval 0.38 to 1.09), and for clonidine versus propofol, it was 0.78 (95% confidence interval 0.45 to 1.34). For the 'feel they can communicate' comparison, the dexmedetomidine versus propofol group odds ratio was 1.00 (95% confidence interval 0.68 to 1.47), and for clonidine versus propofol, it was 1.05 (95% confidence interval 0.71 to 1.54).
LIMITATIONS: Interventions were unblinded, with risk of bias; missing data may not have been at random.
CONCLUSIONS: Nurses perceived patients receiving dexmedetomidine-based sedation could better communicate pain than with propofol-based sedation, and relatives perceived patients appeared more awake. No differences for the other questions were found, or for the clonidine versus propofol comparisons, although some uncertainty remains due to the wide confidence intervals.
FUTURE WORK: Additional mixed-methods research of sedation quality with different agents from staff and relative perspectives.
FUNDING: This article presents independent research funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme as award number 16/93/01.