Anales de pediatria · 2026
The impact of very early and early enteral nutrition on intestinal permeability in children with pancreatitis: A randomized controlled study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Bukowski Jan Stanisław, Jamer Tatiana, Kowalska-Duplaga Kinga, Stelmaszczyk-Emmel Anna, Banasiuk Marcin, Banaszkiewicz Aleksandra
Аннотация
INTRODUCTION AND OBJECTIVES: One of the pathophysiological mechanisms of acute pancreatitis (AP) is the reduced integrity of the intestinal mucosa. Enteral nutrition supports the gut barrier, but its effect on intestinal permeability in pediatric AP has not yet been evaluated. The aim of this study was to assess how very early enteral nutrition (within 24hours of admission) and early enteral nutrition (after the first 24hours) affect plasma zonulin levels in children with mild-to-moderate AP.
METHODS: We conducted a prospective randomized study between January 2019 and September 2022 in three university hospitals. It included children aged 1 to 18 years with AP. Patients were randomly assigned to one of two groups: (A) refeeding within 24hours of admission (very early nutrition) or (B) refeeding at least 24hours after admission (early nutrition). Blood samples and clinical data were collected during the first 3 days of the hospital stay.
RESULTS: Zonulin concentrations were measured in 61 children (37 in group A and 24 in group B). The groups did not differ significantly in age, weight, height, body mass index, AP diagnostics, or laboratory results. Zonulin levels were comparable in both groups throughout the first 3 days of hospitalization.
CONCLUSION: In children with mild pancreatitis, very early enteral nutrition does not appear to affect intestinal barrier permeability, as assessed by plasma zonulin levels, compared to early nutrition.
METHODS: We conducted a prospective randomized study between January 2019 and September 2022 in three university hospitals. It included children aged 1 to 18 years with AP. Patients were randomly assigned to one of two groups: (A) refeeding within 24hours of admission (very early nutrition) or (B) refeeding at least 24hours after admission (early nutrition). Blood samples and clinical data were collected during the first 3 days of the hospital stay.
RESULTS: Zonulin concentrations were measured in 61 children (37 in group A and 24 in group B). The groups did not differ significantly in age, weight, height, body mass index, AP diagnostics, or laboratory results. Zonulin levels were comparable in both groups throughout the first 3 days of hospitalization.
CONCLUSION: In children with mild pancreatitis, very early enteral nutrition does not appear to affect intestinal barrier permeability, as assessed by plasma zonulin levels, compared to early nutrition.