Leptomeninges: Anatomy, Mechanisms of Disease and Neuroimaging.

BACKGROUND

The leptomeninges, comprising the arachnoid and pia mater, serve essential roles in protecting the brain and facilitating cerebrospinal fluid (CSF) circulation. Their significance extends beyond structural support, affecting brain development and function.

METHODS

This study synthesizes findings from various anatomical, embryological, and neuroimaging research to elucidate the complexities of the leptomeninges. Key methodologies include historical anatomical analysis, contemporary imaging techniques, and examination of pathological states.

RESULTS

The review highlights the role of leptomeningeal structures in CSF dynamics, neurovascular interactions, and their involvement in conditions such as hydrocephalus and neurodevelopmental disorders. These insights underscore the leptomeninges' critical involvement in both normal physiology and disease states.

CONCLUSIONS

Understanding the intricacies of leptomeningeal anatomy and function is vital for advancing diagnostic and therapeutic approaches in neurodegenerative disorders. This knowledge may facilitate better management strategies in clinical practice, particularly concerning conditions that disrupt CSF flow and brain health.