Infection · 2019
Ceftaroline as salvage therapy for complicated MRSA bacteremia: case series and analysis.
СтатьяНазвание и аннотация: Перевод в очереди
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Bhowmick Tanaya, Liu Charles, Imp Brandon, Sharma Ranita, Boruchoff Susan E
Аннотация
INTRODUCTION: Methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection (BSI) is a major cause of morbidity and mortality in hospitalized patients. Ceftaroline fosamil (CPT) is the only available beta-lactam antibiotic with in vitro and in vivo activities against MRSA. There is currently limited clinical experience with CPT in complicated MRSA BSI.
MATERIALS AND METHODS: We report a series of eight patients, including three whose strains had reduced susceptibility to vancomycin.
RESULTS: CPT monotherapy was successfully used as salvage therapy for complicated MRSA BSI. The median time to documented clearance was 7 days.
CONCLUSION: Ceftaroline monotherapy is effective for clearance of refractory MRSA BSI related to implanted devices, endocarditis, and orthopedic infections.
MATERIALS AND METHODS: We report a series of eight patients, including three whose strains had reduced susceptibility to vancomycin.
RESULTS: CPT monotherapy was successfully used as salvage therapy for complicated MRSA BSI. The median time to documented clearance was 7 days.
CONCLUSION: Ceftaroline monotherapy is effective for clearance of refractory MRSA BSI related to implanted devices, endocarditis, and orthopedic infections.