Archives of medical research · 2026
Comparison of Health-Related Quality of Life by Sex Across Renal Replacement Therapy Modalities.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Figueroa-García Juan, Hernández-Rivera Juan Carlos H, Espinoza-Pérez Ramón, Padilla-Corral Ana Elizabeth, Guillen-Graf Aurora Estefanía, Ramos-Gordillo Jesús Manolo, García-Covarrubias Luis, Montes-Osorio Mario German, Rojano-Mejía David
Аннотация
BACKGROUND: Advanced chronic kidney disease (ACKD) severely impairs health-related quality of life (HRQoL). Comparative HRQoL outcomes across renal replacement therapy (RRT) modalities and stratified by sex remain poorly characterized in Latin American settings. We compared HRQoL between women and men undergoing peritoneal dialysis (PD), hemodialysis (HD), or kidney transplantation (KT) in Mexico City.
METHODS: A cross-sectional study that examined 300 adults (100 per RRT group; 50 women and 50 men in each) was conducted at the Instituto Mexicano del Seguro Social. HRQoL was measured using the validated Spanish version of the Kidney Disease Quality of Life-36 (KDQoL-36) questionnaire. Multivariable generalized linear models with robust standard errors were used to estimate adjusted marginal means while controlling for age, education, marital status, BMI, and disease duration. Pairwise comparisons were Bonferroni-adjusted.
RESULTS: KT patients showed higher SF-12 Physical Composite scores than PD and HD patients. PD scored lower than HD and KT on the Symptoms/Problems and Effects of Kidney Disease subscales (all p <0.001). HD showed the highest SF-12 Mental Composite score. Sex differences were modest. Within the HD group, women scored higher on the Effects of Kidney Disease subscale (Δ +9.0 [95% CI 1.5-16.4], p = 0.018) but lower on SF-12 Mental Composite subscale (Δ -4.4 [95% CI -8.1 to -0.8], p = 0.018).
CONCLUSION: KT was associated with the best HRQoL and PD showed the lowest scores. Sex differences were limited to mental health and kidney disease burden among HD patients, underscoring the need for modality-specific, sex-sensitive approaches in RRT care.
METHODS: A cross-sectional study that examined 300 adults (100 per RRT group; 50 women and 50 men in each) was conducted at the Instituto Mexicano del Seguro Social. HRQoL was measured using the validated Spanish version of the Kidney Disease Quality of Life-36 (KDQoL-36) questionnaire. Multivariable generalized linear models with robust standard errors were used to estimate adjusted marginal means while controlling for age, education, marital status, BMI, and disease duration. Pairwise comparisons were Bonferroni-adjusted.
RESULTS: KT patients showed higher SF-12 Physical Composite scores than PD and HD patients. PD scored lower than HD and KT on the Symptoms/Problems and Effects of Kidney Disease subscales (all p <0.001). HD showed the highest SF-12 Mental Composite score. Sex differences were modest. Within the HD group, women scored higher on the Effects of Kidney Disease subscale (Δ +9.0 [95% CI 1.5-16.4], p = 0.018) but lower on SF-12 Mental Composite subscale (Δ -4.4 [95% CI -8.1 to -0.8], p = 0.018).
CONCLUSION: KT was associated with the best HRQoL and PD showed the lowest scores. Sex differences were limited to mental health and kidney disease burden among HD patients, underscoring the need for modality-specific, sex-sensitive approaches in RRT care.