Journal of perinatology : official journal of the California Perinatal Association · 2025
Time to positive blood cultures in neonatal sepsis evaluations.
СтатьяНазвание и аннотация: Перевод в очереди
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Willey Emily, Mitchell Michelle, Ehlert Carey, Swoveland Jacob, Zembles Tracy
Аннотация
OBJECTIVE: This study evaluates the time to blood culture positivity among neonates evaluated for sepsis to determine when antibiotics may be safely discontinued.
STUDY DESIGN: Retrospective review of clinically relevant blood culture time to positivity from infants in a neonatal intensive care unit. The primary endpoint was overall median time to blood culture positivity. Secondary endpoints compared time to positivity among gram-positive versus gram-negative organisms, early versus late onset sepsis, and a sub-analysis excluding contaminants.
RESULT: Among 151 cultures, the overall median time to positivity was 17 h (IQR 12-23). Most (47/48, 97.9%) gram-negative organisms resulted within 24 h and most (88/94, 93.6%) gram-positive by 36 h. All (13/13, 100%) early onset cultures resulted within 24 h and most (132/138, 95.7%) late onset by 36 h.
CONCLUSION: Antibiotics for neonatal sepsis evaluation may be safely discontinued in well-appearing infants without an identified infection source with negative cultures at 36 h.
STUDY DESIGN: Retrospective review of clinically relevant blood culture time to positivity from infants in a neonatal intensive care unit. The primary endpoint was overall median time to blood culture positivity. Secondary endpoints compared time to positivity among gram-positive versus gram-negative organisms, early versus late onset sepsis, and a sub-analysis excluding contaminants.
RESULT: Among 151 cultures, the overall median time to positivity was 17 h (IQR 12-23). Most (47/48, 97.9%) gram-negative organisms resulted within 24 h and most (88/94, 93.6%) gram-positive by 36 h. All (13/13, 100%) early onset cultures resulted within 24 h and most (132/138, 95.7%) late onset by 36 h.
CONCLUSION: Antibiotics for neonatal sepsis evaluation may be safely discontinued in well-appearing infants without an identified infection source with negative cultures at 36 h.