Prenatal diagnosis · 2026
Perinatally Accessible Biomarkers of Complex Gastroschisis: Systematic Review and Individual Patient Data Meta-Analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод в очереди
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Arai Tomohiro, Tianthong Wasinee, Russo Francesca Maria, Joyeux Luc, De Coppi Paolo, Deprest Jan
Аннотация
OBJECTIVE: To systematically review perinatally accessible body fluid biomarkers of gastroschisis and those associated with disease severity or postnatal morbidities.
METHODS: PubMed, Embase, Web of Science, Scopus, Cochrane CENTRAL, ClinicalTrials.gov, and the International Clinical Trials Registry Platform were searched for studies reporting body fluid biomarkers obtained from women carrying a fetus or neonates with gastroschisis. The primary aim was to identify biomarkers indicating gastroschisis; secondary aims included identifying biomarkers associated with disease severity (simple vs. complex) or postnatal morbidity.
RESULTS: Twenty-two studies were included, showing substantial heterogeneity in sampling timing, fluid type, and biomarkers assessed. Among 13 studies reporting prenatal biomarkers, amniotic fluid total protein, IL-8, and ferritin differentiated fetuses with gastroschisis from normal fetuses. Total protein correlated with disease severity. Bile acid findings were inconsistent. Increased cord blood IL-8 at delivery was associated with the presence of gastroschisis and prolonged parenteral nutrition. Neonatal urinary intestinal fatty acid-binding protein indicated the presence and severity of gastroschisis. An individual patient data meta-analysis of three studies identified four inflammatory cord blood biomarkers (IL-8, CXCL10, IL-4, and CX3CL1) associated with prolonged parenteral nutrition.
CONCLUSIONS: Several perinatally accessible biomarkers are associated with gastroschisis, and some further correlate with severity or postnatal morbidity.
METHODS: PubMed, Embase, Web of Science, Scopus, Cochrane CENTRAL, ClinicalTrials.gov, and the International Clinical Trials Registry Platform were searched for studies reporting body fluid biomarkers obtained from women carrying a fetus or neonates with gastroschisis. The primary aim was to identify biomarkers indicating gastroschisis; secondary aims included identifying biomarkers associated with disease severity (simple vs. complex) or postnatal morbidity.
RESULTS: Twenty-two studies were included, showing substantial heterogeneity in sampling timing, fluid type, and biomarkers assessed. Among 13 studies reporting prenatal biomarkers, amniotic fluid total protein, IL-8, and ferritin differentiated fetuses with gastroschisis from normal fetuses. Total protein correlated with disease severity. Bile acid findings were inconsistent. Increased cord blood IL-8 at delivery was associated with the presence of gastroschisis and prolonged parenteral nutrition. Neonatal urinary intestinal fatty acid-binding protein indicated the presence and severity of gastroschisis. An individual patient data meta-analysis of three studies identified four inflammatory cord blood biomarkers (IL-8, CXCL10, IL-4, and CX3CL1) associated with prolonged parenteral nutrition.
CONCLUSIONS: Several perinatally accessible biomarkers are associated with gastroschisis, and some further correlate with severity or postnatal morbidity.