Journal of the Saudi Heart Association · 2026
Value of the Non-enhanced Cardiac Computed Tomography Scan Analysis in Determination of the Appropriate Coronary CT Angiography Scan Protocol.
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ALGhasab Naif S, Alshehri Bandar, ALMesned Sulaman, Harbi Hassan, ALAmeer Reem, ALShehri Fahad, ALZeid Ahmad, ALZhrani Meshari, ALMutiri Ghazi T, Al-Saud Sara A, Alobaid Fahad, Alnajashi Khalid S, Fogacci Federica, Cicero Arrigo F G, Kharabsheh Suleiman M
Аннотация
OBJECTIVE: Dextrocardia refers to the right-sided positioning of the heart during embryonic development and may occur in isolation or in association with visceral malposition or other malformations. However, few studies have investigated this condition. This study aimed to determine the incidence of cardiac and non-cardiac malformations, as well as to analyze long-term follow-up and survival outcomes in patients with dextrocardia.
METHODS: This was a retrospective chart review of dextrocardia cases at King Faisal Specialist Hospital & Research Centre in Riyadh, Saudi Arabia from April 22, 1975, to December 31, 2016. A total of 259,246 transthoracic echocardiograms from that period were reviewed, and 357 patients were included in the analysis.
RESULTS: The incidence of dextrocardia was approximately 1 in 28,571 pregnancies (0.35 per 10,000 pregnancies). Most patients with dextrocardia were between 2 and 18 years old (n = 252, 70.6 %). The most common type was isolated dextrocardia (situs solitus), followed by situs inversus totalis, and situs ambiguous. The most common congenital cyanotic heart diseases were double outlet right ventricle (n = 55, 15.5 %) and pulmonary atresia (n = 35, 9.8 %). The most common acyanotic congenital abnormalities were ventricular (n = 152, 42.7 %) and atrial (n = 121, 34.2 %) septal defects. Overall survival in the study population was approximately 83 %. Survival rates varied by situs type, with the highest rates observed in patients with situs inversus (96 %), followed by those with situs solitus (91 %), and situs ambiguous (55 %). Moderate to severe pulmonary hypertension was significantly associated with a reduction in overall survival. The most common non-cardiac anomalies observed were gastrointestinal and urogenital abnormalities.
CONCLUSION: This study describes the largest regional cohort of patients with dextrocardia, providing important insights into dextrocardia and outcomes of different intracardiac defects in our community. Our findings confirm that complex congenital cardiac disease is more common in patients with situs solitus and isomerism group. Patients in the isomerism group (12.6 %) had significantly higher mortality rates compared to those in the situs solitus (7.6 %) and situs inversus (3.7 %) groups.
METHODS: This was a retrospective chart review of dextrocardia cases at King Faisal Specialist Hospital & Research Centre in Riyadh, Saudi Arabia from April 22, 1975, to December 31, 2016. A total of 259,246 transthoracic echocardiograms from that period were reviewed, and 357 patients were included in the analysis.
RESULTS: The incidence of dextrocardia was approximately 1 in 28,571 pregnancies (0.35 per 10,000 pregnancies). Most patients with dextrocardia were between 2 and 18 years old (n = 252, 70.6 %). The most common type was isolated dextrocardia (situs solitus), followed by situs inversus totalis, and situs ambiguous. The most common congenital cyanotic heart diseases were double outlet right ventricle (n = 55, 15.5 %) and pulmonary atresia (n = 35, 9.8 %). The most common acyanotic congenital abnormalities were ventricular (n = 152, 42.7 %) and atrial (n = 121, 34.2 %) septal defects. Overall survival in the study population was approximately 83 %. Survival rates varied by situs type, with the highest rates observed in patients with situs inversus (96 %), followed by those with situs solitus (91 %), and situs ambiguous (55 %). Moderate to severe pulmonary hypertension was significantly associated with a reduction in overall survival. The most common non-cardiac anomalies observed were gastrointestinal and urogenital abnormalities.
CONCLUSION: This study describes the largest regional cohort of patients with dextrocardia, providing important insights into dextrocardia and outcomes of different intracardiac defects in our community. Our findings confirm that complex congenital cardiac disease is more common in patients with situs solitus and isomerism group. Patients in the isomerism group (12.6 %) had significantly higher mortality rates compared to those in the situs solitus (7.6 %) and situs inversus (3.7 %) groups.