The American journal on addictions · 2026
Brief report: Ketamine-assisted "bridge therapy" for opioid tapering in complex cases.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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de Oliveira Mariana C, de Araujo Palmeira Cláudia C, Negrão André B, Hadi Ziyad A, Arana Julia R, de Cássia Ferreira Duarte Rita, da Silva Joice L P, Matsui Gustavo K, Rapozero João F D, Crispim Douglas H, Malbergier André, Castaldelli-Maia João M
Аннотация
BACKGROUND: Opioid use disorder (OUD) presents major challenges, especially when combined with chronic pain and psychiatric comorbidities. A 25-year-old woman with OUD, chronic pain, and major depressive disorder underwent an 8-week protocol of intravenous ketamine infusions (0.5 mg/kg weekly) as an adjunct to opioid tapering.
RESULTS: Methadone dosage was reduced by 50%, with improved pain and craving control, reduced withdrawal symptoms, and greater psychotherapy engagement.
DISCUSSION AND CONCLUSIONS: Ketamine-assisted "bridge therapy" treatment may support opioid tapering in complex cases.
SCIENTIFIC SIGNIFICANCE: This is a novel report to document a multifaceted improvement in this specific comorbidity cluster.
RESULTS: Methadone dosage was reduced by 50%, with improved pain and craving control, reduced withdrawal symptoms, and greater psychotherapy engagement.
DISCUSSION AND CONCLUSIONS: Ketamine-assisted "bridge therapy" treatment may support opioid tapering in complex cases.
SCIENTIFIC SIGNIFICANCE: This is a novel report to document a multifaceted improvement in this specific comorbidity cluster.