Journal of endodontics · 2010
Effect of pretreatment prednisolone on postendodontic pain: a double-blind parallel-randomized clinical trial.
Сравнительное исследованиеСтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Jalalzadeh Seyed Mohsen, Mamavi Ahmad, Shahriari Shahriar, Santos Fábio André, Pochapski Márcia Thaís
Аннотация
INTRODUCTION: Effective management of endodontic pain represents a continuing challenge. This study evaluates the use of a preoperative, single oral dose of prednisolone for the prevention and control of postendodontic pain.
METHODS: Forty patients were randomly assigned to 2 groups, placebo and prednisolone (30 mg). The medications were administered 30 minutes before the start of standard endodontic treatment. Postoperative pain was assessed after 6, 12, and 24 hours by using a visual analogue scale.
RESULTS: The outcome showed that prednisolone resulted in a statistically significant reduction in postendodontic pain at 6, 12, and 24 hours (P < .0001). No side effects were reported for any of the medications used.
CONCLUSIONS: This study suggests that a preoperative, single oral dose of prednisolone substantially reduced postendodontic pain. Further studies are needed to evaluate the applicability of these findings to other clinical conditions, single- versus multiple-visit endodontic treatment, and drug regimens.
METHODS: Forty patients were randomly assigned to 2 groups, placebo and prednisolone (30 mg). The medications were administered 30 minutes before the start of standard endodontic treatment. Postoperative pain was assessed after 6, 12, and 24 hours by using a visual analogue scale.
RESULTS: The outcome showed that prednisolone resulted in a statistically significant reduction in postendodontic pain at 6, 12, and 24 hours (P < .0001). No side effects were reported for any of the medications used.
CONCLUSIONS: This study suggests that a preoperative, single oral dose of prednisolone substantially reduced postendodontic pain. Further studies are needed to evaluate the applicability of these findings to other clinical conditions, single- versus multiple-visit endodontic treatment, and drug regimens.
Предметные рубрики MeSH
Administration, OralAdolescentAdultAnalgesics, Non-NarcoticAnti-Inflammatory AgentsBismuthDouble-Blind MethodEpoxy ResinsFemaleGlucocorticoidsGutta-PerchaHumansMaleMiddle AgedPain MeasurementPostoperative PainPlacebosPrednisolonePremedicationRoot Canal Filling MaterialsRoot Canal PreparationRoot Canal TherapySilverTitaniumTooth, NonvitalYoung Adult