Movement disorders : official journal of the Movement Disorder Society · 2026
Nongenetic Factors Associated with Age at Onset and Disease Severity in Spinocerebellar Ataxia Type 3: A Cross-Sectional Cohort Study.
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He Jiawei, Chen Zhao, Zeng Linyi, Peng Linliu, Hu Jian, Ouyang Riwei, Deng Qi, Yuan Hongyu, Wan Na, Gong Yiqing, Tan Yan, Ding Siyu, Tang Cuiling, Shen Xiaokai, Dong Mengyuan, Lei Lijing, Wu Qi, Peng Jinzi, Huang Qinlin, He Lang, Wang Chunrong, Wan Linlin, Long Zhe, Tang Beisha, Qiu Rong, Jiang Hong
Аннотация
BACKGROUND: Beyond genetic factors, demographic and environmental associations with onset and severity in spinocerebellar ataxia type 3 (SCA3) remain incompletely understood.
OBJECTIVE: The aim of this study was to identify the association of nongenetic factors with onset and severity of SCA3.
METHODS: Associations of nongenetic factors with age at onset (AAO) or Scale for the Assessment and Rating of Ataxia (SARA) scores were examined using generalized linear models.
RESULTS: In the cohort of 324 patients with SCA3, higher education level was associated with lower SARA scores but earlier AAO. Smoking was associated with earlier AAO. Tea consumption was inversely associated with SARA scores. Body mass index, coffee consumption, alcohol consumption, as well as other assessed variables, were not associated with AAO or SARA scores.
CONCLUSIONS: These findings support the associations of nongenetic factors and onset or severity in SCA3, while highlighting the need for cautious interpretation given the observational design. © 2026 International Parkinson and Movement Disorder Society.
OBJECTIVE: The aim of this study was to identify the association of nongenetic factors with onset and severity of SCA3.
METHODS: Associations of nongenetic factors with age at onset (AAO) or Scale for the Assessment and Rating of Ataxia (SARA) scores were examined using generalized linear models.
RESULTS: In the cohort of 324 patients with SCA3, higher education level was associated with lower SARA scores but earlier AAO. Smoking was associated with earlier AAO. Tea consumption was inversely associated with SARA scores. Body mass index, coffee consumption, alcohol consumption, as well as other assessed variables, were not associated with AAO or SARA scores.
CONCLUSIONS: These findings support the associations of nongenetic factors and onset or severity in SCA3, while highlighting the need for cautious interpretation given the observational design. © 2026 International Parkinson and Movement Disorder Society.