Topical application of the tricyclic antidepressant doxepin can reduce dysuria and frequency.

The aim of this article is to highlight a novel treatment for the symptoms of chronic urethral and trigonal irritation. A patient with severe urethral hyperaesthesia who derived almost complete alleviation of symptoms with topical application of a tricyclic antidepressant cream is described. The possible modes of action of tricyclics when used via the topical route of administration are described. Topical application of a tricyclic antidepressant cream may alleviate the symptoms of urethral hyperaesthesia.