BMC nephrology · 2019
Reduced membrane attack complex formation in umbilical cord blood during Eculizumab treatment of the mother: a case report.
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Nagarajah Subagini, Tepel Martin, Nielsen Christian, Assing Kristian, Palarasah Yaseelan, Andersen Lise Lotte Torvin, Lange Lotte Borg, Bistrup Claus
Аннотация
BACKGROUND: Atypical hemolytic uremic syndrome (aHUS) is a disorder of the microvasculature with hemolytic anemia, thrombocytopenia and acute kidney injury. Nowadays, aHUS is successfully treated with eculizumab, a humanized, chimeric IgG2/4 kappa antibody, which binds human complement C5 and blocks generation of C5a and membrane-attack-complex.
CASE PRESENTATION: A 25-year-old woman with end stage renal disease due to relapsing atypical hemolytic uremic syndrome had a relapse of the disease during pregnancy. She was treated with eculizumab. We measured reduced formation of the membrane-attack complex in newborn's umbilical cord vein blood using the sensitive and specific Palarasah-Nielsen-ELISA.
CONCLUSIONS: Eculizumab treatment of the mother with end stage renal disease may cause reduced innate immunity which could render newborns more susceptible to infections.
CASE PRESENTATION: A 25-year-old woman with end stage renal disease due to relapsing atypical hemolytic uremic syndrome had a relapse of the disease during pregnancy. She was treated with eculizumab. We measured reduced formation of the membrane-attack complex in newborn's umbilical cord vein blood using the sensitive and specific Palarasah-Nielsen-ELISA.
CONCLUSIONS: Eculizumab treatment of the mother with end stage renal disease may cause reduced innate immunity which could render newborns more susceptible to infections.
Предметные рубрики MeSH
AdultAntibodies, Monoclonal, HumanizedAtypical Hemolytic Uremic SyndromeComplement C3Complement C5aComplement C9Complement Inactivating AgentsComplement Membrane Attack ComplexEnzyme-Linked Immunosorbent AssayFemaleFetal BloodHumansInfant, NewbornKidney Failure, ChronicPregnancyPregnancy ComplicationsRecurrence