Drug-Induced Enterocolitis Syndrome: An Updated Review of Diagnosis and Management.

Drug-induced enterocolitis syndrome (DIES), first described in 2014, is a poorly understood condition caused by a non-IgE-mediated hypersensitivity reaction to a drug. The pathophysiology of this condition remains to be fully elucidated. The symptoms are characterized by profuse vomiting, hypotension, pallor, lethargy, abdominal pain, and diarrhea, and the condition can progress to dehydration and hypovolemic shock. We aimed to review published cases to date and report a case recently diagnosed at our center. Additionally, we discuss and suggest recommendations for the current diagnostic criteria of this disease, the approach to drug provocation tests, and available therapeutic alternatives.