European journal of pediatrics · 2026
Is small for gestational age associated with reduced oxygen saturation to FiO2 ratio at 36 weeks postmenstrual age in preterm infants, independent of bronchopulmonary dysplasia? A retrospective Italian two-center cohort study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Correani Alessio, Lanciotti Lucia, Giorgetti Chiara, Burattini Ilaria, Fattore Simona, Esposito Alice, Costa Simonetta, Tirone Chiara, Vento Giovanni, Carnielli Virgilio
Аннотация
UNLABELLED: The overrepresentation of small-for-gestational-age (SGA) preterm infants among those with bronchopulmonary dysplasia (BPD) poses a challenge in quantifying the extent to which SGA independently affects respiratory outcomes. This two-center study aims to evaluate whether SGA status at birth is associated with reduced oxygen saturation (SpO2) to fraction inspired oxygen (FiO2) ratio (SFR) at 36 weeks (W) in preterm infants, independent of BPD. We retrospectively reviewed clinical data of preterm infants born between 24+0/7 and 30+6/7W of gestational age (GA). SGA was defined as a birth weight < 10th percentile according to Italian charts. BPD was diagnosed based on physiological definition. The primary outcome was the lowest quartile (Q1) of SFR at 36W. The association of SGA with Q1-SFR at 36W was evaluated using multiple regressions. Among 1,380 eligible infants, the incidences of SGA and BPD were 19.4% and 19.5%, respectively. SGA incidence was higher in infants with BPD than noBPD (30.1% vs 16.8%, p < 0.001). Among the 1,243 infants alive at 36W, 1,116 (89.8%) had available SFR data. After adjustment for BPD, GA, sex, Apgar score, brain injury, postnatal corticosteroids, and study center, SGA was significantly associated with 3.6-fold increased risk of Q1-SFR at 36W. In infants without BPD, SGA remained associated with an increased risk of Q1-SFR at 36W (aOR: 4.298, p < 0.001).
CONCLUSIONS: In preterm infants (GA 24+0/7-30+6/7W), SGA status at birth is associated with reduced SFR at 36W postmenstrual age, independent of BPD. Coordinated optimization of prenatal and neonatal care remains crucial to mitigate respiratory impairment in this high-risk population.
WHAT IS KNOWN: • Bronchopulmonary dysplasia (BPD) is one of the most relevant respiratory complications in preterm infants. • Small-for-gestational-age (SGA) preterm infants are at higher risk of BPD.
WHAT IS NEW: • In a large two-center cohort of very preterm infants (24+0/7-30+6/7 weeks) without BPD, SGA at birth was independently associated with reduced oxygen saturation to fraction inspired oxygen ratio (SFR) at 36 weeks. • SGA should be considered an independent risk factor when assessing respiratory outcomes in preterm infants.
CONCLUSIONS: In preterm infants (GA 24+0/7-30+6/7W), SGA status at birth is associated with reduced SFR at 36W postmenstrual age, independent of BPD. Coordinated optimization of prenatal and neonatal care remains crucial to mitigate respiratory impairment in this high-risk population.
WHAT IS KNOWN: • Bronchopulmonary dysplasia (BPD) is one of the most relevant respiratory complications in preterm infants. • Small-for-gestational-age (SGA) preterm infants are at higher risk of BPD.
WHAT IS NEW: • In a large two-center cohort of very preterm infants (24+0/7-30+6/7 weeks) without BPD, SGA at birth was independently associated with reduced oxygen saturation to fraction inspired oxygen ratio (SFR) at 36 weeks. • SGA should be considered an independent risk factor when assessing respiratory outcomes in preterm infants.