International journal of cardiology. Congenital heart disease · 2026
Pregnancy in women with vascular Ehlers-Danlos syndrome: a case series from the registry of pregnancy and cardiac disease (ROPAC) III.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Peters P N J, van der Zande J A, Prakash S K, Harris J, Troost E, Tobler D, Bouma B J, Roos-Hesselink J W, ROPAC investigators
Аннотация
BACKGROUND: Vascular Ehlers-Danlos syndrome (vEDS) is a rare connective tissue disorder associated with high pregnancy-related risks. Current guidelines consider vEDS an mWHO IV high-risk pregnancy, but data are limited and often retrospective.
METHODS: This prospective case series reports pregnancy outcomes and aortic measurements in six women with confirmed or suspected vEDS enrolled in the ROPAC III registry.
RESULTS: No maternal deaths or aortic dissections occurred. One fetal death was reported. Obstetric complications were common, including preterm birth and hemorrhage. Most women delivered via cesarean section. No significant aortic growth was observed during pregnancy.
CONCLUSIONS: In women diagnosed with vEDS prior to pregnancy, the absence of life-threatening vascular events suggests pregnancy may be safer than previously reported. These findings support more individualized counseling and underscore the need for further prospective studies.
METHODS: This prospective case series reports pregnancy outcomes and aortic measurements in six women with confirmed or suspected vEDS enrolled in the ROPAC III registry.
RESULTS: No maternal deaths or aortic dissections occurred. One fetal death was reported. Obstetric complications were common, including preterm birth and hemorrhage. Most women delivered via cesarean section. No significant aortic growth was observed during pregnancy.
CONCLUSIONS: In women diagnosed with vEDS prior to pregnancy, the absence of life-threatening vascular events suggests pregnancy may be safer than previously reported. These findings support more individualized counseling and underscore the need for further prospective studies.