The Japanese journal of antibiotics · 1982
[Infections during induction chemotherapy of acute leukemia and their control V. Clinical evaluation of a large dose of amikacin injected intravenously].
Клинический случайАннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Moriyama Y, Urushiyama M, Ohnishi M, Koyama S, Hirosawa H, Hanano M, Fuse I, Takai K, Nagayama R, Fujiwara M, Kishi K, Takahashi M, Koike T, Takahashi H, Sakai C, Aoyagi Y, Sanada M, Hattori A, Shibata A
Аннотация
In this study, we treated severe infections (21 cases) accompanied with induction chemotherapy in 20 patients with acute leukemia by the combination of a large dose (600 approximately 1,200 mg/day) of amikacin with other antibiotics. Infections during induction chemotherapy of acute leukemia consisted of sepsis (8 cases), pneumonia (7) and others (6), and most of causative organisms were Gram-negative bacteria, such as Ps. aeruginosa (7 strains), Flavobacterium (5), Serratia (3), Ps. cepacia (2), E. coli (2) and others. The combination chemotherapy of a large dose of amikacin with other antibiotics was found to be effective (71.4%) for such infections. Side effects were negligible except for drug eruption. Therefore, a large dose of amikacin should be given for the treatment of severe infections accompanied with induction chemotherapy of acute leukemia.