Journal of perinatology : official journal of the California Perinatal Association · 2026
Association between vasoactive-inotropic score, clinical outcomes, defect size and laterality in congenital diaphragmatic hernia.
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Beverstock Andrew M, Hagan Joseph L, Hanna Morcos, Fernandes Caraciolo J, Gowda Sharada H
Аннотация
OBJECTIVE: To assess whether vasoactive-inotropic score (VIS) during early life was predictive of outcomes for infants with congenital diaphragmatic hernia and to determine whether VIS differed by defect size and laterality.
STUDY DESIGN: Retrospective single-center cohort study of 206 infants with CDH. VIS was calculated at 6, 12, 24, 48 and 72 h of life as well as at repair, 24 h and 48 h-post repair.
RESULT: Higher VIS scores at all time points were associated with an increased risk of mechanical ventilation at 28 days of life (p < 0.02). VIS in the first 24 h was associated with an increased risk ECMO or death (p < 0.001) and tracheostomy or death (p < 0.02). VIS did not differ between left and right defects, but larger defects had higher scores.
CONCLUSION: Early-life VIS scores at 6, 12 and 24 h have predictive value for extended duration of mechanical ventilation, ECMO, tracheostomy or death.
STUDY DESIGN: Retrospective single-center cohort study of 206 infants with CDH. VIS was calculated at 6, 12, 24, 48 and 72 h of life as well as at repair, 24 h and 48 h-post repair.
RESULT: Higher VIS scores at all time points were associated with an increased risk of mechanical ventilation at 28 days of life (p < 0.02). VIS in the first 24 h was associated with an increased risk ECMO or death (p < 0.001) and tracheostomy or death (p < 0.02). VIS did not differ between left and right defects, but larger defects had higher scores.
CONCLUSION: Early-life VIS scores at 6, 12 and 24 h have predictive value for extended duration of mechanical ventilation, ECMO, tracheostomy or death.