Frontiers in endocrinology · 2025
Frozen-thawed double cleavage-stage or frozen-thawed single day 6 blastocyst stage embryo transfer: which is preferable for patients younger than 35 without day 5 blastocyst formation?
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Liu Yan, Wang Taojun, Dai Shanjun, Shi Hao, Sun Yingpu
Аннотация
BACKGROUND: To compare the clinical outcomes between frozen-thawed cleavage embryo transfer and frozen-thawed day 6 blastocyst transfer in patients younger than 35 using the freeze-all strategy without day 5 blastocyst formation.
METHODS: This was a retrospective observational analysis performed between January 2018 and December 2022 at the Reproductive and Genetic Specialist Hospital of the First Affiliated Hospital of Zhengzhou University. A total of 576 patients younger than 35 who used the "freeze-all strategy" but produced no day 5 blastocysts were recruited. The patients were divided into 3 groups according to the number and stage of the transferred embryos: double cleavage-stage embryos (Group A), single good-quality day 6 blastocysts (Group B) and single inferior-quality day 6 blastocysts (Group C),and several pregnancy outcomes were measured.
RESULTS: Groups A and B exhibited significantly higher chemical (73.7%, 67.0% versus 51.9%) and clinical pregnancy rates (69.0%, 59.4% versus 44.2%) than Group C. The implantation rate was significantly higher in Group B than in Groups A and C (59.4% versus 45.7%, 43.5%). The live birth rate was significantly higher in Group A than in Group C (59.2% versus 48.1%). The multiple pregnancy rate was significantly higher in Group A than in Groups B and C (34.4% versus 1.6%, 1.5%). The early miscarriage rate was significantly higher in Group C than in Group A and Group B (23.5% versus 8.7%, 12.7%). Premature delivery rates, late miscarriage rates and ectopic pregnancy rates were comparable across groups.
CONCLUSIONS: A single good quality day 6 blastocyst transfer was the preferable strategy for the freeze-all strategy patients who younger than 35 and without day 5 blastocyst formation.
METHODS: This was a retrospective observational analysis performed between January 2018 and December 2022 at the Reproductive and Genetic Specialist Hospital of the First Affiliated Hospital of Zhengzhou University. A total of 576 patients younger than 35 who used the "freeze-all strategy" but produced no day 5 blastocysts were recruited. The patients were divided into 3 groups according to the number and stage of the transferred embryos: double cleavage-stage embryos (Group A), single good-quality day 6 blastocysts (Group B) and single inferior-quality day 6 blastocysts (Group C),and several pregnancy outcomes were measured.
RESULTS: Groups A and B exhibited significantly higher chemical (73.7%, 67.0% versus 51.9%) and clinical pregnancy rates (69.0%, 59.4% versus 44.2%) than Group C. The implantation rate was significantly higher in Group B than in Groups A and C (59.4% versus 45.7%, 43.5%). The live birth rate was significantly higher in Group A than in Group C (59.2% versus 48.1%). The multiple pregnancy rate was significantly higher in Group A than in Groups B and C (34.4% versus 1.6%, 1.5%). The early miscarriage rate was significantly higher in Group C than in Group A and Group B (23.5% versus 8.7%, 12.7%). Premature delivery rates, late miscarriage rates and ectopic pregnancy rates were comparable across groups.
CONCLUSIONS: A single good quality day 6 blastocyst transfer was the preferable strategy for the freeze-all strategy patients who younger than 35 and without day 5 blastocyst formation.